Bridges C H, Camp B J, Livingston C W, Bailey E M
Department of Veterinary Pathology, Texas A&M University, College Station.
Vet Pathol. 1987 Nov;24(6):525-31. doi: 10.1177/030098588702400609.
Twenty-four lambs grazing pastures of Panicum coloratum developed photosensitization secondary to hepatic dysfunction. Lesions were necrosis of scattered hepatocytes, obstruction of small bile ducts and bile canaliculi by small aggregates of birefringent crystals, and accumulation of birefringent crystals in phagocytes within sinusoids. The number of crystals in livers of affected sheep varied, depending on the amount of time of exposure to toxic plants and severity of hepatic abnormalities. Crystals in the liver were soluble in acidified ethyl alcohol, acetic acid, pyridine, chloral hydrate, and methanol, but not in xylene, petroleum ether, diethyl ether, acetone, water, or cold ethyl alcohol. Crystals were not stained by oil red O. There was necrosis of epithelial cells in renal distal convoluted tubules, papillary muscles of the heart, and the adrenal cortex. Lesions of Panicum coloratum-associated disease are similar to those associated with photosensitization induced by Tribulus terrestris, Agave lecheguilla, and Nolina texana.
24只在巴哈雀稗牧场上放牧的羔羊因肝功能障碍继发光敏反应。病变包括散在肝细胞坏死、小胆管和胆小管被双折射晶体小聚集体阻塞，以及肝血窦内吞噬细胞中双折射晶体的蓄积。患病绵羊肝脏中晶体的数量各不相同，这取决于接触有毒植物的时间长短和肝脏异常的严重程度。肝脏中的晶体可溶于酸化乙醇、乙酸、吡啶、水合氯醛和甲醇，但不溶于二甲苯、石油醚、乙醚、丙酮、水或冷乙醇。晶体不能被油红O染色。肾远曲小管、心脏乳头肌和肾上腺皮质的上皮细胞发生坏死。巴哈雀稗相关疾病的病变与刺蒺藜、龙舌兰和德州诺林草引起的光敏反应相关病变相似。
