Department of Clinical and Experimental Medicine, Section of Psychiatry, University of Pisa, Italy.
Saint Camillus International University of Health and Medical Sciences, Rome, Italy.
Curr Med Chem. 2022;29(36):5758-5781. doi: 10.2174/0929867328666210922160116.
Major depressive disorder (MDD) and bipolar disorders (BDs), the most severe types of mood disorders (MDs), are considered as among the most disabling illnesses worldwide. Several studies suggested that inflammatory neuroinflammation might be involved in the pathophysiology of MDs while reporting increasing data on the relationships between these processes and classical neurotransmitters, hypothalamus-pituitaryadrenal axis (HPA), and neurotrophic factors. The assessment of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and monocyte/lymphocyte ratio (MLR) in peripheral blood represents a simple method to evaluate the inflammatory status. The aim of the present paper was to review the literature on the possible relationships between NLR, PLR, and MLR in MDs and to comment on their possible wider use in clinical research. Thirty-five studies were included in the present review. The majority of them had higher values of these parameters, particularly NLR values in patients with MDs when compared to healthy subjects. The increase would appear more robust in patients with BD during a manic episode, thus indicating that it could be considered as both state and trait markers. In addition, increased NLR and PLR levels seem to represent prognostic elements for the early discovery of post-stroke depression. The findings of the present review would indicate the need to carry out further studies in this field. In particular, NLR, PLR, and MLR seem to be promising tools to detect economically and easily the activation of the inflammatory system and to perhaps evaluate the etiology and course of MDs. Again, they could suggest some information to better understand the relationship between inflammatory and cardiovascular disease and MDs, and thus, to provide clinical implications in terms of management and treatment.
重性抑郁障碍（MDD）和双相情感障碍（BD）是最严重的心境障碍（MD）类型，被认为是全球最致残的疾病之一。几项研究表明，炎症性神经炎症可能与 MD 的病理生理学有关，同时也报告了越来越多的关于这些过程与经典神经递质、下丘脑-垂体-肾上腺轴（HPA）和神经营养因子之间关系的数据。外周血中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）和单核细胞/淋巴细胞比值（MLR）的评估是评估炎症状态的一种简单方法。本研究旨在综述 NLR、PLR 和 MLR 与 MD 之间可能的关系，并对其在临床研究中的可能更广泛应用进行评论。本综述共纳入 35 项研究。其中大多数研究的这些参数值较高，尤其是 MD 患者的 NLR 值与健康受试者相比。在躁狂发作期间，BD 患者的增加似乎更为明显，因此表明其可能被视为状态和特征标志物。此外，NLR 和 PLR 水平的升高似乎代表了早期发现中风后抑郁的预后因素。本综述的研究结果表明需要在这一领域开展进一步的研究。特别是，NLR、PLR 和 MLR 似乎是一种有前途的工具，可以经济、简便地检测炎症系统的激活情况，并可能评估 MD 的病因和病程。此外，它们可以提供一些关于炎症与心血管疾病和 MD 之间关系的信息，从而在管理和治疗方面提供临床意义。
