Laboratory of Bio-molecular Technology, Department of Botany, Mohanlal Sukhadia University, Udaipur, Rajasthan, 313001, India.
Biol Futur. 2020 Sep;71(3):195-208. doi: 10.1007/s42977-020-00042-4. Epub 2020 Sep 5.
Bioactive peptides (BPs) are 3-20 amino acid residues, with a molecular weight lower than 6 kDa; originated from the breakdown of proteins by endogenous and exogenous peptidases. While intact in protein these peptides do not exert any biological activity, but as they release from their parent protein, they exert various pharmacological activities such as antidiabetic, antihypertensive, anticancerous, anti-inflammatory, antimicrobial, antioxidant, and immunomodulatory. Such peptides exist in all living organism like plants, animals, marine organism and also present in food products derived from them. BPs obtained from dairy food products, cereals, vegetables have been gaining much more importance now-a-days, but little work has been done on bioactive peptides obtained from medicinal plants. Some of the medicinal plants such as Tinospora cordifolia Sterculia foetida, Benincasa hispida, Parkia speciosa, Linum usitatissimum, Salvia hispanica and Ziziphus jujube have been explored for bioactive peptides. Current review is aimed to provide a complete information of medicinal plants derived BPs along with the surge of new materials, new plants which will provide more solutions for handling some of the major human health problems of twenty-first century. This review will also be helpful to researchers in providing valuable information about the extraction, separation, characterization of BPs, their known peptide sequences and various pharmacological activities exerted by medicinal plants-derived bioactive peptides.
生物活性肽（BPs）是 3-20 个氨基酸残基，分子量低于 6 kDa；由内源性和外源性肽酶对蛋白质的分解产生。这些肽在蛋白质中是完整的，不会发挥任何生物活性，但当它们从其母体蛋白中释放出来时，它们会发挥各种药理活性，如抗糖尿病、抗高血压、抗癌、抗炎、抗菌、抗氧化和免疫调节。这种肽存在于所有生物中，如植物、动物、海洋生物，也存在于它们衍生的食品中。如今，从乳制品、谷物、蔬菜中获得的 BP 受到了更多的关注，但从药用植物中获得的生物活性肽的研究工作却很少。一些药用植物，如三叶鬼针草、诃子、冬瓜、百脉根、芝麻菜和枣，已经被探索用于生物活性肽。本综述旨在提供有关药用植物来源 BP 的完整信息，以及新材料、新植物的涌现，这将为解决 21 世纪人类的一些主要健康问题提供更多的解决方案。这篇综述也将有助于研究人员提供关于 BP 的提取、分离、特性鉴定、已知肽序列以及药用植物来源的生物活性肽发挥的各种药理活性方面的有价值的信息。
