Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas.
Baylor College of Medicine, Houston, Texas.
J Am Acad Dermatol. 2022 Jun;86(6):1337-1345. doi: 10.1016/j.jaad.2021.09.024. Epub 2021 Sep 20.
Antibiotic resistance is a growing health concern that has attracted increasing attention from clinicians and scientists in recent years. Although resistance is an inevitable consequence of bacterial evolution and natural selection, misuse and overuse of antibiotics play a significant role in its acceleration. Antibiotics are the mainstay of therapy for common dermatoses, including acne and rosacea, as well as for skin and soft tissue infections. Therefore, it is critical for dermatologists and physicians across all disciplines to identify, appropriately manage, and prevent cases of antibiotic resistance. This review explores dermatologic conditions in which the development of antibiotic resistance is a risk and discusses mechanisms underlying the development of resistance. We discuss disease-specific strategies for overcoming resistant strains and improving antimicrobial stewardship along with recent advances in the development of novel approaches to counter antibiotic resistance.
抗生素耐药性是一个日益严重的健康问题，近年来引起了临床医生和科学家的越来越多的关注。尽管耐药性是细菌进化和自然选择的必然结果，但抗生素的滥用和过度使用在其加速发展中起着重要作用。抗生素是治疗常见皮肤病（包括痤疮和酒渣鼻）以及皮肤和软组织感染的主要方法。因此，皮肤科医生和所有学科的医生都必须识别、适当管理和预防抗生素耐药性病例。这篇综述探讨了抗生素耐药性发展风险的皮肤科疾病，并讨论了耐药性发展的机制。我们讨论了针对特定疾病的克服耐药菌株的策略，并改善抗菌药物管理，以及新型方法对抗抗生素耐药性的最新进展。
