听觉惊跳反应的获得呈现出对血清游离甲状腺素的剂量反应。

Acquisition of acoustic startle shows a dose-response to serum free T4.

作者信息

Schneider B F, Golden W L

机构信息

Department of Developmental Genetics and Anatomy, Case Western Reserve University, Cleveland, OH 44106.

出版信息

Int J Dev Neurosci. 1986;4(4):397-400. doi: 10.1016/0736-5748(86)90057-2.

DOI:10.1016/0736-5748(86)90057-2

PMID:3455599

Abstract

Methimazole, administered to rats in drinking water (0.1 and 0.05%) from embryonic day 17 to postnatal day 10, caused a dose-dependent decrease in serum Free T4 and an accompanying dose dependent delay in acquisition of acoustic startle reflex. In conjunction with other studies showing the specific dependence of acoustic startle development on thyroid hormone, this study suggests that the acoustic startle system may be a useful model for determining thyroid hormone requirements for normal neurologic development.

摘要

从胚胎第17天到出生后第10天，给大鼠饮用含0.1%和0.05%甲巯咪唑的水，结果导致血清游离甲状腺素呈剂量依赖性降低，同时获得听觉惊吓反射的时间也出现剂量依赖性延迟。结合其他显示听觉惊吓发育对甲状腺激素有特定依赖性的研究，本研究表明，听觉惊吓系统可能是确定正常神经发育所需甲状腺激素的有用模型。