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成年急性呼吸道疾病患者的双重呼吸道病毒检测

Dual respiratory virus detection in adult patients with acute respiratory illness.

作者信息

Lee Yu-Mi, Kim Tark, Park Ki-Ho, Choi Seong-Ho, Kwak Yee Gyung, Choo Eun Ju, Chung Jin-Won, Lee Mi Suk

机构信息

Division of Infectious Diseases, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, Republic of Korea.

Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.

出版信息

BMC Infect Dis. 2021 Sep 23;21(1):997. doi: 10.1186/s12879-021-06699-z.

DOI:10.1186/s12879-021-06699-z
PMID:34556046
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8460188/
Abstract

BACKGROUND

Nonrandom multiple respiratory virus (RV) detection provides evidence for viral interference among respiratory viruses. However, little is known as to whether it occurs randomly.

METHODS

The prevalence of dual RV detection (DRVD) in patients with acute respiratory illnesses (ARIs) at 4 academic medical centers was investigated; data about the prevalence of 8 RVs were collected from the Korean national RV surveillance dataset. Linear regression analysis was performed to assess the correlation between observed and estimated prevalence of each type of DRVD.

RESULTS

In total, 108 patients with ARIs showing DRVD were included in this study between 2011 and 2017. In several types of regression analysis, a strong correlation was observed between the observed and estimated prevalence of each type of DRVD. Excluding three DRVD types (influenza/picornavirus, influenza/human metapneumovirus, and adenovirus/respiratory syncytial virus), the slope of the regression line was higher than that of the line of random occurrence (1.231 > 1.000) and the 95% confidence interval of the regression line was located above the line of random occurrence.

CONCLUSIONS

Contrary to the results of previous epidemiologic studies, most types of DRVD occur more frequently than expected from the prevalence rates of individual RV, except for three underrepresented pairs above.

摘要

背景

非随机的多种呼吸道病毒（RV）检测为呼吸道病毒之间的病毒干扰提供了证据。然而，对于其是否随机发生却知之甚少。

方法

调查了4家学术医疗中心急性呼吸道疾病（ARI）患者中双重RV检测（DRVD）的患病率；从韩国全国RV监测数据集中收集了8种RV的患病率数据。进行线性回归分析以评估每种DRVD观察到的患病率与估计患病率之间的相关性。

结果

2011年至2017年期间，本研究共纳入了108例显示DRVD的ARI患者。在几种类型的回归分析中，观察到每种DRVD观察到的患病率与估计患病率之间存在很强的相关性。排除三种DRVD类型（流感/小RNA病毒、流感/人偏肺病毒和腺病毒/呼吸道合胞病毒）后，回归线的斜率高于随机发生线的斜率（1.231＞1.000），且回归线的95%置信区间位于随机发生线之上。

结论

与先前的流行病学研究结果相反，除上述三种代表性不足的配对外，大多数类型的DRVD发生频率高于根据单个RV患病率预期的频率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c78/8461985/74d53edfd940/12879_2021_6699_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c78/8461985/0a24129a6020/12879_2021_6699_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c78/8461985/6fd8b90d4676/12879_2021_6699_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c78/8461985/74d53edfd940/12879_2021_6699_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c78/8461985/0a24129a6020/12879_2021_6699_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c78/8461985/6fd8b90d4676/12879_2021_6699_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c78/8461985/74d53edfd940/12879_2021_6699_Fig3_HTML.jpg

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