Santos Diego Junior da Silva, Jr Jonas Capelli
Department of Preventive and Community Dentistry, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Private Practice, Rio de Janeiro, Brazil.
Korean J Orthod. 2021 Sep 25;51(5):346-354. doi: 10.4041/kjod.2021.51.5.346.
To compare the effectiveness of ibuprofen, acetaminophen, and chewing gum for orthodontic pain relief and to assess if chewing gum can be a non-pharmacological alternative for orthodontic pain relief.
The study enrolled 106 patients of both sexes, aged ≥ 12 years, with body weight > 50 kg, and mild-to-moderate dental crowding in the upper arch. After randomization and allocation concealment, the intervention groups were either administered with ibuprofen (400 mg) or acetaminophen (500 mg) or chewed sugar-free chewing gum immediately after initial archwire placement and every 6 hours for 1 week if the pain persisted. The control group did not receive any pain relief. The pain was assessed on a 100-mm visual analog scale at rest and while biting down at T1 (2 hours), T2 (24 hours), T3 (2 days), T4 (3 days), T5 (7 days), and T6 (21 days). Statistical analyses were performed using the Kruskal-Wallis and post-hoc Mann-Whitney U tests (α = 0.05).
The chewing gum group experienced more pain relief than the ibuprofen group at while biting down at T3 ( = 0.04) and at rest at T4 ( < 0.001). The chewing gum group reported more pain relief than the acetaminophen and control groups while biting down at T3 ( = 0.03 and = 0.0006, respectively) and T4 (both < 0.001).
Chewing gum can be a non-pharmacological alternative for orthodontic pain relief at 2 and 3 days after initial archwire placement.
比较布洛芬、对乙酰氨基酚和口香糖缓解正畸疼痛的效果，并评估口香糖是否可作为缓解正畸疼痛的非药物替代方法。
本研究纳入了106例年龄≥12岁、体重>50 kg、上颌轻度至中度牙列拥挤的男女患者。经过随机分组和分配隐藏后，干预组在初次放置弓丝后立即服用布洛芬（400 mg）或对乙酰氨基酚（500 mg），或咀嚼无糖口香糖，若疼痛持续则每6小时重复一次，持续1周。对照组未接受任何止痛治疗。在静息状态及咬合时，于T1（2小时）、T2（24小时）、T3（2天）、T4（3天）、T5（7天）和T6（21天）使用100 mm视觉模拟量表评估疼痛程度。采用Kruskal-Wallis检验和事后Mann-Whitney U检验进行统计分析（α = 0.05）。
在T3咬合时（P = 0.04）和T4静息时（P < 0.001），口香糖组比布洛芬组疼痛缓解更明显。在T3咬合时（分别为P = 0.03和P = 0.0006）和T4时（均为P < 0.001），口香糖组比乙酰氨基酚组和对照组疼痛缓解更明显。
在初次放置弓丝后2至3天，口香糖可作为缓解正畸疼痛的非药物替代方法。
