斑马鱼的分离分析和基因-着丝粒距离
Segregation analyses and gene-centromere distances in zebrafish.
作者信息
Streisinger G, Singer F, Walker C, Knauber D, Dower N
出版信息
Genetics. 1986 Feb;112(2):311-9. doi: 10.1093/genetics/112.2.311.
Abstract
The gol-1, gol-2, alb-1 and spa-1 mutations affect pigment pattern in the zebrafish. We show here that these loci are unlinked to each other. In addition, gene-centromere distances were determined for these loci by analysis of half-tetrads obtained by the inhibition of the second meiotic division. The fractions of tetratype (second-division segregation) tetrads range from 0.24 (spa-1) to 0.89 (gol-1). The observation of greater than 0.67 second-division segregation indicates that the zebrafish has high chiasma interference.
摘要
gol-1、gol-2、alb-1和spa-1突变会影响斑马鱼的色素模式。我们在此表明，这些基因座彼此不连锁。此外，通过分析抑制第二次减数分裂获得的半四分体，确定了这些基因座与着丝粒的距离。四型（第二次分裂分离）四分体的比例范围从0.24（spa-1）到0.89（gol-1）。大于0.67的第二次分裂分离的观察结果表明斑马鱼具有高度的交叉干涉。
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