中国农村50岁以上成年人单纯糖耐量受损的流行病学研究

Epidemiology of Isolated Impaired Glucose Tolerance Among Adults Aged Above 50 Years in Rural China.

作者信息

Tian Xiaobing, Li Yan, Liu Jie, Lin Qiuxing, Yang Qiaoxia, Tu Jun, Wang Jinghua, Li Jidong, Ning Xianjia

机构信息

Department of Neurology, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.

Center of Clinical Epidemiology & Evidence-Based Medicine, The Jizhou People's Hospital, Tianjin, People's Republic of China.

出版信息

Diabetes Metab Syndr Obes. 2021 Sep 16;14:4067-4078. doi: 10.2147/DMSO.S330470. eCollection 2021.

DOI:10.2147/DMSO.S330470

PMID:34557009

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8453426/

Abstract

INTRODUCTION

Isolated impaired glucose tolerance (i-IGT) is a subtype of prediabetes in which an individual demonstrates elevated 2-h post-glucose load glucose levels but normal fasting plasma glucose levels. However, few studies have explored the prevalence and risk factors of i-IGT among adults in rural China. Thus, we aimed to explore the prevalence and risk factors of i-IGT among adults ≥50 years old in a low-income, rural population in China.

MATERIALS AND METHODS

Individuals aged ≥50 years with normal fasting plasma glucose levels were included in the final analysis. Fasting and 2-h venous blood samples were collected to assess the selected parameter measurements.

RESULTS

A total of 2175 individuals were included in this study. The i-IGT prevalence was 22.9% and significantly higher among females than among males (P<0.05). Older age [odds ratio (OR), 1.606; 95% confidence interval (CI), 1.101-2.342; P=0.014), hypertension (OR, 1.554; 95% CI, 1.152-2.019; P=0.004), and central obesity (OR, 1.395; 95% CI, 1.099-1.771; P=0.006) were associated with i-IGT. Moreover, white blood cell (OR, 1.089; 95% CI, 1.009-1.175; P=0.029), high-sensitivity C-reactive protein (OR, 1.049; 95% CI, 1.020-1.078; P=0.001), serum uric acid (OR, 1.0003; 95% CI, 1.001-1.004; P=0.001), triglyceride (OR, 1.540; 95% CI, 1.105-2.147; P=0.011), and alanine aminotransferase (OR, 1.012; 95% CI, 1.004-1.021; P=0.004) levels were also linked to i-IGT in the analyzed population.

CONCLUSION

Health promotion education and a standardized approach to managing body weight, BP, and lipid and uric acid levels would benefit this low-income population in rural China for reducing the risk of cardiovascular disease.

摘要

引言

单纯糖耐量受损（i-IGT）是糖尿病前期的一种亚型，个体在葡萄糖负荷后2小时血糖水平升高，但空腹血糖水平正常。然而，很少有研究探讨中国农村成年人中i-IGT的患病率及危险因素。因此，我们旨在探讨中国低收入农村地区≥50岁成年人中i-IGT的患病率及危险因素。

材料与方法

最终分析纳入空腹血糖水平正常的≥50岁个体。采集空腹和2小时静脉血样本以评估选定参数测量值。

结果

本研究共纳入2175名个体。i-IGT患病率为22.9%，女性显著高于男性（P<0.05）。年龄较大[比值比（OR），1.606；95%置信区间（CI），1.101 - 2.342；P = 0.014]、高血压（OR，1.554；95% CI，1.152 - 2.019；P = 0.004）和中心性肥胖（OR，1.395；95% CI，1.099 - 1.771；P = 0.006）与i-IGT相关。此外，在所分析人群中，白细胞（OR，1.089；95% CI，1.009 - 1.175；P = 0.029）、高敏C反应蛋白（OR，1.049；95% CI，1.020 - 1.078；P = 0.001）、血清尿酸（OR，1.0003；95% CI，1.001 - 1.004；P = 0.001）、甘油三酯（OR，1.540；95% CI，1.105 - 2.147；P = 0.011）和丙氨酸氨基转移酶（OR，1.012；95% CI，1.004 - 1.021；P = 0.004）水平也与i-IGT有关。