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在从热应激中恢复的过程中，动机性位移试验可区分ALA神经元突变体和RIS神经元突变体。

Motivated displacement assay distinguishes ALA neuron mutants from RIS neuron mutants during recovery from heat stress in .

作者信息

Chávez-Pérez Carlos, Jafari Niusha, Keenan Brendan T, Raizen David M, Rohacek Alex M

机构信息

Department of Neurology, Perelman School of Medicine, University of Pennsylvania.

Division of Sleep Medicine, Department of Medicine, Perelman School of Medicine, University of Pennsylvania.

出版信息

MicroPubl Biol. 2021 Sep 20;2021. doi: 10.17912/micropub.biology.000468. eCollection 2021.

DOI:10.17912/micropub.biology.000468
PMID:34557657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8453304/
Abstract

The interneurons ALA and RIS both regulate stress induced sleep in but their roles in awake animal movement has been reported to differ. We describe the development of a motivated mobility-based assay that distinguishes between animals mutant for ALA function and those mutant for RIS function.

摘要

中间神经元ALA和RIS都调节应激诱导的睡眠，但据报道它们在清醒动物运动中的作用有所不同。我们描述了一种基于动机性移动的检测方法的开发，该方法可以区分ALA功能突变的动物和RIS功能突变的动物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00f6/8453304/5d111721dd8a/25789430-2021-micropub.biology.000468.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00f6/8453304/5d111721dd8a/25789430-2021-micropub.biology.000468.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00f6/8453304/5d111721dd8a/25789430-2021-micropub.biology.000468.jpg

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本文引用的文献

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2
Cellular damage, including wounding, drives stress-induced sleep.包括受伤在内的细胞损伤会引发应激诱导的睡眠。
J Neurogenet. 2020 Sep-Dec;34(3-4):430-439. doi: 10.1080/01677063.2020.1752203. Epub 2020 May 2.
3
A salt-induced kinase is required for the metabolic regulation of sleep.盐诱导激酶是睡眠代谢调节所必需的。
PLoS Biol. 2020 Apr 21;18(4):e3000220. doi: 10.1371/journal.pbio.3000220. eCollection 2020 Apr.
4
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Curr Biol. 2020 Jan 6;30(1):1-16.e13. doi: 10.1016/j.cub.2019.10.048. Epub 2019 Dec 12.
5
Forward Genetic Screen for Mutants with a Shortened Locomotor Healthspan.用于筛选运动寿命缩短的突变体的正向遗传学筛选
G3 (Bethesda). 2019 Aug 8;9(8):2415-2423. doi: 10.1534/g3.119.400241.
6
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7
Call it Worm Sleep.称之为蠕虫睡眠。
Trends Neurosci. 2016 Feb;39(2):54-62. doi: 10.1016/j.tins.2015.12.005. Epub 2015 Dec 30.
8
Cellular stress induces a protective sleep-like state in C. elegans.细胞应激在秀丽隐杆线虫中诱导出一种类似睡眠的保护状态。
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