The occurrence of the 15;17 translocation in acute promyelocytic leukemia.
作者信息
De Braekeleer M, Lin C C
出版信息
Cancer Genet Cytogenet. 1986 Jan 15;19(3-4):311-9. doi: 10.1016/0165-4608(86)90060-9.
PMID:3455847
Abstract
For many years, acute promyelocytic leukemia (APL) has been associated with the 15;17 translocation. However, questions concerning an eventual geographic distribution have been raised by the Second and Fourth International Workshops on Chromosomes in Leukemia. Using a statistical approach, we showed that, even if the techniques of processing play an important role in detecting the 15;17 translocation, a geographic distribution exists, which is difficult to explain. Finally, we discuss the possible role of c-erb A1 in acute promyelocytic leukemia.
摘要
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