Sonoda Y, Misawa S, Maekawa T, Taniwaki M, Abe T, Takino T
Cancer Genet Cytogenet. 1985 May;17(1):61-7. doi: 10.1016/0165-4608(85)90102-5.
We report a 36-year-old male with typical features of acute promyelocytic leukemia (APL) in whom a new variant 15;17 translocation, t(8p+;17q-), was found. Using G- and Q- banding techniques, the chromosome breaks were found to be near the junction of 8p12 and 8p21 and band 17q12, respectively. The breakpoint on 17q in our case was similar to that in previously described cases with a standard translocation (15;17). Consequently, this chromosome break or rearrangement at band 17q12, rather than the recipient site of translocation of the deleted material, appears to be of crucial importance in the genesis of APL.
我们报告了一名36岁男性，具有急性早幼粒细胞白血病（APL）的典型特征，在其体内发现了一种新的15;17易位变体，即t(8p+;17q-)。使用G显带和Q显带技术，发现染色体断裂分别位于8p12与8p21交界处附近以及17q12带。我们病例中17q上的断点与先前描述的具有标准易位（15;17）的病例中的断点相似。因此，17q12带处的这种染色体断裂或重排，而非缺失物质易位的接受位点，似乎在APL的发生中至关重要。
