National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
Front Public Health. 2022 Jul 13;10:923968. doi: 10.3389/fpubh.2022.923968. eCollection 2022.
Pulmonary non-tuberculous mycobacteria (NTM) infection has become a public health concern in China and around the world. The objective of this study was to describe the longitudinal changes in the frequency and diversity of NTM in northern China.
We retrospectively analyzed data on mycobacterium species in Beijing Chest Hospital from January 2014 to December 2021. The isolates were identified to species level by targeted DNA sequencing.
After excluding duplicates, 1,755 NTM strains were analyzed, which were from 27 provinces in China over 8 years. Among all mycobacteria, the proportion of NTM increased each year, from 4.24% in 2014 to 12.68% in 2021. Overall, 39 different NTM species were identified, including 23 slow growing mycobacteria (SGM) and 16 rapid growing mycobacteria (RGM). The most common species were (51.62%), (22.22%), (8.32%), (7.75%) and (2.05%). The number of NTM species identified also increased each year from 9 in 2014 to 26 in 2021. Most species showed stable isolation rates over the years; however, the proportion of increased from 3.85 to 10.42% during the study period. Besides, 81 non-mycobacteria strains, including (21 isolates), (19 isolates) and (17 isolates), etc., were also discovered.
The proportion of NTM and species diversity increased considerably in northern China from 2014 to 2021. was the most common NTM isolated among respiratory specimens, followed by and . Rare NTM species and non-mycobacteria pathogens also need attention.
肺非结核分枝杆菌（NTM）感染已成为中国乃至全球的公共卫生关注点。本研究旨在描述中国北方 NTM 的频率和多样性的纵向变化。
我们回顾性分析了 2014 年 1 月至 2021 年 12 月北京胸科医院分枝杆菌菌种的数据。通过靶向 DNA 测序将分离株鉴定到种水平。
排除重复后，分析了来自中国 27 个省的 1755 株 NTM 菌株。在所有分枝杆菌中，NTM 的比例逐年增加，从 2014 年的 4.24%增加到 2021 年的 12.68%。总体而言，共鉴定出 39 种不同的 NTM 菌种，包括 23 株慢生长分枝杆菌（SGM）和 16 株快生长分枝杆菌（RGM）。最常见的菌种分别是 （51.62%）、 （22.22%）、 （8.32%）、 （7.75%）和 （2.05%）。每年鉴定出的 NTM 菌种数量也从 2014 年的 9 种增加到 2021 年的 26 种。大多数菌种多年来的分离率保持稳定；然而， （从 3.85%增加到 10.42%）在研究期间的比例增加。此外，还发现了 81 株非分枝杆菌菌株，包括 （21 株）、 （19 株）和 （17 株）等。
2014 年至 2021 年，中国北方 NTM 的比例和多样性显著增加。在呼吸道标本中分离出的最常见 NTM 是 ，其次是 和 。稀有 NTM 菌种和非分枝杆菌病原体也需要关注。
