Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany.
Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.
Magn Reson Imaging. 2021 Dec;84:41-57. doi: 10.1016/j.mri.2021.09.006. Epub 2021 Sep 21.
Magnetic resonance imaging is used to stage thyroid tumors. Diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) can be used to reflect tumor microstructure. Our aim was to compare ADC values of malignant and benign thyroid lesions based on a large sample.
MEDLINE library, EMBASE and SCOPUS databases were screened for the associations between ADC values and thyroid lesions up to August 2021. The primary endpoint of the systematic review were ADC values of benign and malignant thyroid lesions. In total, 29 studies were suitable for the analysis and were included into the present study.
The included studies comprised a total of 2137 lesions, 1118 (52.3%) benign and 1019 (47.7%) malignant lesions. The pooled mean ADC value of the benign thyroid lesions was 1.88 × 10 mm/s [95% CI 1.77-2.0] and the pooled mean ADC value of malignant thyroid lesions was 1.15 × 10 mm/s [95% CI 1.04-1.25].
ADC can well discriminate benign and malignant thyroid tumors. Therefore, DWI should be implemented into the presurgical diagnostic work-up in clinical routine.
磁共振成像（MRI）用于甲状腺肿瘤分期。扩散加权成像（DWI）和表观扩散系数（ADC）可用于反映肿瘤的微观结构。我们的目的是基于大样本比较良、恶性甲状腺病变的 ADC 值。
截至 2021 年 8 月，我们对 MEDLINE 文库、EMBASE 和 SCOPUS 数据库进行了筛选，以寻找 ADC 值与甲状腺病变之间的关联。系统评价的主要终点为良性和恶性甲状腺病变的 ADC 值。共有 29 项研究适合分析，并纳入本研究。
纳入的研究共包括 2137 个病灶，其中良性病变 1118 个（52.3%），恶性病变 1019 个（47.7%）。良性甲状腺病变的平均 ADC 值为 1.88×10mm/s[95%CI 1.77-2.0]，恶性甲状腺病变的平均 ADC 值为 1.15×10mm/s[95%CI 1.04-1.25]。
ADC 能很好地区分良、恶性甲状腺肿瘤。因此，DWI 应在临床常规术前诊断工作中得到实施。
