Department of Plastic Surgery, University of Kansas Medical Center.
University of Kansas School of Medicine, Kansas City, KS.
J Craniofac Surg. 2022 May 1;33(3):870-874. doi: 10.1097/SCS.0000000000008201. Epub 2021 Sep 23.
Although pathology in the maxillary and mandibular bones is rare in young patients, the differential diagnosis is broad. The World Health Organization (WHO) updated its classification of maxillofacial bone pathology in 2017. Using these updated guidelines, a systematic review of common maxillofacial bone lesions in the pediatric population was performed.
A PubMed search was conducted capturing English language articles from inception to July 2020. Thirty-one articles were identified that described the frequency of maxillofacial bone pathology. Data were extracted and organized using the WHO 2017 classification of odontogenic and maxillofacial bone tumors. Prevalence data were analyzed among diagnostic categories and geographical regions. The SAS version 9.4 was used to complete statistical analyses.
The articles included patients from birth to a maximum age of 14 to 19 years. The most common odontogenic cysts included radicular cyst (42.7%) and dentigerous cyst (39.0%) followed by odontogenic keratocyst (15.0%). Among odontogenic bone tumors, odontoma (49.3%) was most common followed by ameloblastoma (29.1%). The most common nonodontogenic bone tumor was fibrous dysplasia (42.4%), and the most common malignant bone tumor was osteosarcoma (75.0%). Significant variations were found by geographic region, with dentigerous cyst more common than radicular cyst, and ameloblastoma more common than odontoma in African and Asian countries (P < 0.0001).
This systematic review uses the WHO 2017 guidelines to classify common odontogenic and nonodontogenic maxillofacial bone lesions around the world. Pathogenesis, presentation, and available treatment options for the most common maxillofacial bone lesions are reviewed.
尽管上颌骨和下颌骨的病理学在年轻患者中较为罕见，但鉴别诊断范围广泛。世界卫生组织（WHO）于 2017 年更新了颌面骨病理学分类。使用这些更新的指南，对儿科人群常见的颌面骨病变进行了系统综述。
在 PubMed 上进行了检索，收录了从创建到 2020 年 7 月的英语文章。确定了 31 篇描述颌面骨病理学频率的文章。使用 WHO 2017 年牙源性和颌面骨肿瘤分类提取和组织数据。在诊断类别和地理区域之间分析流行率数据。使用 SAS 版本 9.4 完成统计分析。
这些文章纳入了从出生到 14 至 19 岁的患者。最常见的牙源性囊肿包括根型囊肿（42.7%）和含牙囊肿（39.0%），其次是牙源性角化囊肿（15.0%）。在牙源性骨肿瘤中，牙瘤（49.3%）最为常见，其次是成釉细胞瘤（29.1%）。最常见的非牙源性骨肿瘤是纤维结构不良（42.4%），最常见的恶性骨肿瘤是骨肉瘤（75.0%）。不同地理区域之间存在显著差异，非洲和亚洲国家的含牙囊肿比根型囊肿更常见，成釉细胞瘤比牙瘤更常见（P<0.0001）。
本系统综述使用 WHO 2017 指南对全球常见的牙源性和非牙源性颌面骨病变进行分类。回顾了最常见的颌面骨病变的发病机制、表现和可用的治疗选择。
