Friedland G H, Saltzman B R, Rogers M F, Kahl P A, Lesser M L, Mayers M M, Klein R S
N Engl J Med. 1986 Feb 6;314(6):344-9. doi: 10.1056/NEJM198602063140604.
To determine the risk of transmission of human T-cell lymphotropic virus Type III/lymphadenopathy-associated virus (HTLV-III/LAV) to close but nonsexual contacts of patients with the acquired immunodeficiency syndrome (AIDS), we studied the nonsexual household contacts of patients with AIDS or the AIDS-related complex with oral candidiasis. Detailed interviews, physical examinations, and tests for serum antibody to HTLV-III/LAV were performed on 101 household contacts of 39 AIDS patients (68 children and 33 adults), all of whom had lived in the same household with an index patient for at least three months. These contacts had shared household items and facilities and had close personal interaction with the patient for a median of 22 months (range, 3 to 48) during the period of presumed infectivity. Only 1 of 101 household contacts--a five-year-old child--had evidence of infection with the virus, which had probably been acquired perinatally rather than through horizontal transmission. This study indicates that household contacts who are not sexual partners of, or born to, patients with AIDS are at minimal or no risk of infection with HTLV-III/LAV.
为了确定人类Ⅲ型嗜T细胞病毒/淋巴结病相关病毒（HTLV-III/LAV）传播给获得性免疫缺陷综合征（AIDS）患者的密切但非性接触者的风险，我们研究了AIDS患者或伴有口腔念珠菌病的AIDS相关综合征患者的非性家庭接触者。对39例AIDS患者（68名儿童和33名成人）的101名家庭接触者进行了详细访谈、体格检查及HTLV-III/LAV血清抗体检测，所有接触者均与索引患者在同一家庭中生活至少3个月。在假定的感染期内，这些接触者共用家庭物品和设施，与患者有密切的个人互动，时间中位数为22个月（范围3至48个月）。101名家庭接触者中只有1名——一名5岁儿童——有病毒感染证据，其感染可能是通过围产期获得而非水平传播。本研究表明，非AIDS患者性伴侣或非其子女的家庭接触者感染HTLV-III/LAV的风险极小或无风险。
