Ellis G L, Kratochvil F J
Oral Surg Oral Med Oral Pathol. 1986 Jan;61(1):61-8. doi: 10.1016/0030-4220(86)90204-5.
Epithelioid hemangioendothelioma (EH) is a recently described unusual vascular neoplasm of the soft tissues. Apparently identical tumors have also been described in the lung and and liver. Although no previous reports have described these lesions in the head and neck, twelve cases from this region are reported here. There is a wide age distribution throughout adulthood of affected patients. The 4-year-old patient in this series is the youngest thus far reported. There is no sex predilection. The submandibular region is the head and neck site most frequently involved. The unusual histologic appearance of these tumors is demonstrated by the fact that only one case was originally diagnosed as a vascular neoplasm. Nests and cords of pleomorphic epithelioid cells, spindle cells, and vacuolated cells and a hyalinized or myxochondroid stroma are features that distinguish EH. All eight of the tumors tested showed factor VIII-related antigen immunoreactivity. EH has a biologic potential intermediate between that of hemangioma and conventional angiosarcoma.
上皮样血管内皮瘤（EH）是一种最近才被描述的软组织罕见血管肿瘤。显然，相同的肿瘤也在肺和肝脏中被描述过。尽管之前没有关于头颈部这些病变的报道，但本文报告了该区域的12例病例。受影响患者在整个成年期年龄分布广泛。本系列中的4岁患者是迄今为止报道的最年轻患者。无性别倾向。下颌下区域是头颈部最常受累的部位。这些肿瘤不寻常的组织学表现体现在最初只有一例被诊断为血管肿瘤这一事实上。多形性上皮样细胞、梭形细胞、空泡状细胞巢和索以及玻璃样变或黏液软骨样基质是区分EH的特征。所有检测的8个肿瘤均显示VIII因子相关抗原免疫反应性。EH的生物学潜能介于血管瘤和传统血管肉瘤之间。
