Department of Medicinal & Applied Chemistry, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Research Centre for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
Colloids Surf B Biointerfaces. 2021 Dec;208:112117. doi: 10.1016/j.colsurfb.2021.112117. Epub 2021 Sep 16.
There are certain disadvantages in treating bacterial infections through conventional methods. For this reason, the current study does focus on combating bacterial wound infections by photothermal therapy assisted by gold nanorod-peptide conjugates (GNR-peptide conjugates). Two peptides, the cationic antimicrobial peptide LL-37 and neuropeptide ANGIOPEP-2 both with specificity for targeted bacterial binding, were conjugated with GNR surface through electrostatic interactions. The GNR-peptide conjugates showed good biocompatibility, sufficient stability, enhanced targeting, potential photothermal killing of bacteria, and possible acceleration of wound healing. The photo-biomodulation properties of NIR improved the wound closure rates through enhanced cell migration. The multifunctional LL37-conjugated GNRs significantly enhanced photothermal therapeutic outcomes based on bacterial targeting with promising wound healing properties.
通过传统方法治疗细菌感染存在一定的弊端。出于这个原因，目前的研究确实侧重于通过金纳米棒-肽缀合物（GNR-肽缀合物）辅助的光热疗法来对抗细菌性伤口感染。两种肽，阳离子抗菌肽 LL-37 和神经肽 ANGIOPEP-2，都具有针对靶向细菌结合的特异性，通过静电相互作用与 GNR 表面偶联。GNR-肽缀合物表现出良好的生物相容性、足够的稳定性、增强的靶向性、潜在的光热杀菌作用和可能加速伤口愈合。近红外光的光生物调节特性通过增强细胞迁移来提高伤口闭合率。多功能的 LL37 偶联的 GNRs 基于细菌靶向显著增强了光热治疗效果，具有有前景的伤口愈合特性。
