Yuan Xiangnan, Tan Shaojie, Gao Jing, Wang Lu
Key Laboratory of Biomedical Textile Materials and Technology in Textile Industry, Donghua University, Shanghai 201620, P. R. China.
College of Textiles, Donghua University, Shanghai 201620, P. R. China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2022 Feb 25;39(1):207-216. doi: 10.7507/1001-5515.202103022.
With the development of photothermal nanomaterials, photothermal therapy based on near-infrared light excitation shows great potential for the bacterial infected wound treatment. At the same time, in order to improve the photothermal antibacterial effect of wound infection and reduce the damage of high temperature and heat to healthy tissue, the targeted bacteria strategy has been gradually applied in wound photothermal therapy. In this paper, several commonly used photothermal nanomaterials as well as their targeted bacterial strategies were introduced, and then their applications in photothermal antibacterial therapy, especially in bacterial infected wounds were described. Besides, the challenges of targeted photothermal antibacterial therapy in the wound healing application were analyzed, and the development of photothermal materials with targeted antibacterial property has prospected in order to provide a new idea for wound photothermal therapy.
随着光热纳米材料的发展，基于近红外光激发的光热疗法在细菌感染伤口治疗方面显示出巨大潜力。同时，为了提高伤口感染的光热抗菌效果并减少高温热对健康组织的损伤，靶向细菌策略已逐渐应用于伤口光热疗法。本文介绍了几种常用的光热纳米材料及其靶向细菌策略，然后描述了它们在光热抗菌治疗中的应用，特别是在细菌感染伤口中的应用。此外，分析了靶向光热抗菌疗法在伤口愈合应用中的挑战，并对具有靶向抗菌性能的光热材料的发展进行了展望，以期为伤口光热疗法提供新思路。
