Department of Ophthalmology, Korea University College of Medicine, Seoul, Republic of Korea.
Department of Ophthalmology, Korea University Ansan Hospital, Gyeonggi-do, Republic of Korea.
Cornea. 2022 Apr 1;41(4):427-434. doi: 10.1097/ICO.0000000000002802.
The purpose of this study was to evaluate the efficacy of topical ivermectin 1% cream application on the eyelashes in combination with eyelid hygiene in the treatment of Demodex blepharitis.
One hundred two eyes of 102 patients with symptomatic Demodex blepharitis were divided into 2 groups according to the use of topical ivermectin in this retrospective case-control study. The ivermectin group (n = 51) applied topical ivermectin 1% cream on the eyelashes for 15 minutes once weekly, but the control group (n = 51) did not. In both groups, eyelid hygiene was performed once daily. The Standard Patient Evaluation of Eye Dryness (SPEED) symptom questionnaire score, Oxford staining score, eyelid debris, eyelid redness/swelling, and telangiectasia were assessed during the follow-up visits.
The mean follow-up periods of the ivermectin and control groups were 15.1 ± 9.7 weeks and 14.8 ± 8.6 weeks, respectively. The SPEED score and eyelid debris grade were significantly improved in both groups during the follow-up, although the SPEED score and eyelid debris grade showed greater changes in the ivermectin group than in the control group. The Oxford staining score, eyelid redness/swelling grade, and telangiectasia grade were significantly improved only in the ivermectin group but not in the control group.
In patients with Demodex blepharitis, the use of topical ivermectin 1% cream for 15 minutes once weekly in addition to eyelid hygiene had more significantly improved symptoms, ocular surface staining, eyelid debris, redness/swelling, and telangiectasia as compared with eyelid hygiene alone. These findings support the efficacy of topical ivermectin 1% cream application in the treatment of Demodex blepharitis.
本研究旨在评估在眼睑卫生的基础上，联合使用 1%伊维菌素乳膏涂于睫毛，对蠕形螨性睑缘炎的疗效。
在这项回顾性病例对照研究中，102 例有症状的蠕形螨性睑缘炎患者的 102 只眼根据是否使用伊维菌素分为两组。伊维菌素组（n = 51）每周应用 1%伊维菌素乳膏涂于睫毛 15 分钟，而对照组（n = 51）不使用。两组均每日进行眼睑卫生。在随访期间，评估标准患者眼干燥评估问卷（SPEED）症状评分、牛津染色评分、眼睑碎屑、眼睑红肿/肿胀和毛细血管扩张。
伊维菌素组和对照组的平均随访时间分别为 15.1 ± 9.7 周和 14.8 ± 8.6 周。两组在随访过程中 SPEED 评分和眼睑碎屑分级均显著改善，尽管伊维菌素组的 SPEED 评分和眼睑碎屑分级变化较对照组更大。仅伊维菌素组的牛津染色评分、眼睑红肿/肿胀分级和毛细血管扩张分级显著改善，而对照组无此改善。
与单独进行眼睑卫生相比，每周应用 1%伊维菌素乳膏涂于睫毛 15 分钟联合眼睑卫生治疗蠕形螨性睑缘炎，可更显著地改善症状、眼表面染色、眼睑碎屑、红肿/肿胀和毛细血管扩张。这些发现支持每周应用 1%伊维菌素乳膏治疗蠕形螨性睑缘炎的疗效。
