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免疫性血小板减少症孕妇两种出血评分系统临床应用的比较研究。

Comparative Study of the Clinical Application of 2 Bleeding Grading Systems for Pregnant Women With Immune Thrombocytopenia.

机构信息

Department of Haematology, Fujian Institute of Haematology, Fujian Provincial Key Laboratory on Haematology, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.

出版信息

Clin Appl Thromb Hemost. 2020 Jan-Dec;26:1076029620910790. doi: 10.1177/1076029620910790.

Abstract

To compare the clinical practicability of two bleeding grading systems (BGS) in pregnancy with Immune Thrombocytopenia (ITP). The clinical data of 154 cases were retrospectively analyzed with the 2016 version of the ITP Bleeding Scale (ITP-2016) and the ITP-specific bleeding assessment tool (ITP-BAT). The correlation between the two BGS and the relations among the platelet counts, gestational ages, and disease stages were respectively analyzed. There is no significant difference between the two BGS in the patients' ages, nor between the newly diagnosed and the persistent group or the chronic group, while the difference between the persistent and the chronic group was significant ( = 0.001; = 0.001). There is a negative correlation between the bleeding grade and platelet count (r = -0.436; r = -0.390), while the correlation between the two BGS was positive (r = 0.921). The proportions of identical scores provided by two different physicians using the two BGS were 94.8% and 93.5%. The difference before and after the treatment were significantly different ( = 0.013; = 0.037). It takes less time to score with the ITP-2016 ( = 0.011). Both systems can be useful for disease evaluations, risk assessments and efficacy evaluations in Chinese pregnant women with ITP. The ITP-2016 takes less time and is more suitable for Chinese pregnant patients with ITP.

摘要

比较两种用于妊娠免疫性血小板减少症(ITP)的出血分级系统(BGS)的临床实用性。回顾性分析了 154 例患者的临床数据,使用 2016 年 ITP 出血量表(ITP-2016)和 ITP 特异性出血评估工具(ITP-BAT)。分别分析了两种 BGS 之间的相关性以及血小板计数、孕龄和疾病阶段之间的关系。两种 BGS 在患者年龄、初诊与持续组或慢性组之间均无显著差异,而持续组与慢性组之间差异显著(=0.001;=0.001)。出血等级与血小板计数呈负相关(r=-0.436;r=-0.390),而两种 BGS 之间呈正相关(r=0.921)。两名医生使用两种 BGS 提供相同评分的比例分别为 94.8%和 93.5%。治疗前后差异有统计学意义(=0.013;=0.037)。使用 ITP-2016 评分所需时间更短(=0.011)。两种系统均可用于评估中国妊娠 ITP 患者的疾病、风险和疗效。ITP-2016 所需时间更短,更适合中国妊娠 ITP 患者。

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本文引用的文献

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Thrombocytopenia in pregnancy.妊娠期血小板减少症
Clin Adv Hematol Oncol. 2007 Jan;5(1):43-4.
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The pathogenesis of immune thrombocytopaenic purpura.免疫性血小板减少性紫癜的发病机制。
Br J Haematol. 2006 May;133(4):364-74. doi: 10.1111/j.1365-2141.2006.06024.x.
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Moderate to severe thrombocytopenia during pregnancy.孕期中重度血小板减少症。
Eur J Obstet Gynecol Reprod Biol. 2006 Sep-Oct;128(1-2):163-8. doi: 10.1016/j.ejogrb.2005.12.031. Epub 2006 Mar 13.

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