基里恩萨氏菌引起的非瓣膜性感染性心内膜炎，见于一名再生障碍性贫血免疫功能低下患者
Non-valvular Infective Endocarditis Caused by Sarocladium kiliense in an Immunocompromised Patient with Aplastic Anemia.
作者信息
Kitamura Hiroaki, Kubota Yasushi, Tomimasu Rika, Akashi Michiaki, Mori Tadashi, Mine Yutaro, Ando Jun, Yamagata Murayama Somay, Kimura Shinya, Miyahara Masaharu
机构信息
Department of Internal Medicine, Karatsu Red Cross Hospital, Japan.
Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, Japan.
出版信息
Intern Med. 2022 Apr 15;61(8):1279-1283. doi: 10.2169/internalmedicine.7536-21. Epub 2021 Sep 25.
Sarocladium kiliense is ubiquitous in the human environment and is an emerging opportunistic pathogen, especially among immunocompromised hosts. A 77-year-old man diagnosed with aplastic anemia suffered from non-valvular endocarditis. After he passed away, fungal hyphae were observed in several lesions on a postmortem examination. Polymerase chain reaction (PCR) and a DNA sequence analysis revealed S. kiliense as the causative organism. This is the first case report of non-valvular fungal endocarditis caused by S. kiliense identified by PCR and a DNA sequence analysis in an immunocompromised patient. Although rare, invasive fungal infection caused by S. kiliense should be considered in immunocompromised hosts.
基利恩萨氏菌在人类环境中普遍存在，是一种新兴的机会致病菌，尤其是在免疫功能低下的宿主中。一名77岁被诊断为再生障碍性贫血的男性患有非瓣膜性心内膜炎。他去世后，尸检在多个病灶中观察到真菌菌丝。聚合酶链反应（PCR）和DNA序列分析显示基利恩萨氏菌为病原体。这是首例通过PCR和DNA序列分析在免疫功能低下患者中确诊由基利恩萨氏菌引起的非瓣膜性真菌性心内膜炎的病例报告。尽管罕见，但在免疫功能低下的宿主中应考虑由基利恩萨氏菌引起的侵袭性真菌感染。
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