Yuan Shi-Min
The First Hospital of Putian, Teaching Hospital, Fujian Medical University, Fujian Province, China.
Braz J Cardiovasc Surg. 2016 May-Jun;31(3):252-255. doi: 10.5935/1678-9741.20160026.
Fungal endocarditis is a rare and fatal condition. The Candida and Aspergillus species are the two most common etiologic fungi found responsible for fungal endocarditis. Fever and changing heart murmur are the most common clinical manifestations. Some patients may have a fever of unknown origin as the onset symptom. The diagnosis of fungal endocarditis is challenging, and diagnosis of prosthetic valve fungal endocarditis is extremely difficult. The optimum antifungal therapy still remains debatable. Treating Candida endocarditis can be difficult because the Candida species can form biofilms on native and prosthetic heart valves. Combined treatment appears superior to monotherapy. Combination of antifungal therapy and surgical debridement might bring about better prognosis.
真菌性心内膜炎是一种罕见且致命的疾病。念珠菌属和曲霉菌属是导致真菌性心内膜炎的两种最常见病原真菌。发热和心脏杂音改变是最常见的临床表现。一些患者可能以不明原因发热为首发症状。真菌性心内膜炎的诊断具有挑战性，人工瓣膜真菌性心内膜炎的诊断极其困难。最佳抗真菌治疗方案仍存在争议。治疗念珠菌性心内膜炎可能困难，因为念珠菌属可在天然和人工心脏瓣膜上形成生物膜。联合治疗似乎优于单一疗法。抗真菌治疗与手术清创相结合可能带来更好的预后。
