Zhao Shu-Wan, Xu Xian, Wang Xian-Yang, Yan Tian-Cai, Cao Yang, Yan Qing-Hong, Chen Kun, Jin Yin-Chuan, Zhang Ya-Hong, Yin Hong, Cui Long-Biao
Department of Clinical Psychology, School of Medical Psychology, Fourth Military Medical University, Xi'an, China.
Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Front Hum Neurosci. 2021 Sep 9;15:720239. doi: 10.3389/fnhum.2021.720239. eCollection 2021.
Schizophrenia is a complex mental illness with genetic heterogeneity, which is often accompanied by alterations in brain structure and function. The neurobiological mechanism of schizophrenia associated with heredity remains unknown. Recently, the development of trans-scale and multi-omics methods that integrate gene and imaging information sheds new light on the nature of schizophrenia. In this article, we summarized the results of brain structural and functional changes related to the specific single-nucleotide polymorphisms (SNPs) in the past decade, and the SNPs were divided into non-coding regions and coding regions, respectively. It is hoped that the relationship between SNPs and cerebral alterations can be displayed more clearly and intuitively, so as to provide fresh approaches for the discovery of potential biomarkers and the development of clinical accurate individualized treatment decision-making.
精神分裂症是一种具有遗传异质性的复杂精神疾病，常伴有脑结构和功能的改变。与遗传相关的精神分裂症神经生物学机制尚不清楚。近年来，整合基因和影像信息的跨尺度多组学方法的发展为精神分裂症的本质研究带来了新的启示。本文总结了过去十年中与特定单核苷酸多态性（SNP）相关的脑结构和功能变化结果，这些SNP分别分为非编码区和编码区。希望能更清晰直观地展示SNP与脑改变之间的关系，为发现潜在生物标志物和制定临床精准个体化治疗决策提供新途径。
