Pupíková Monika, Šimko Patrik, Lamoš Martin, Gajdoš Martin, Rektorová Irena
Applied Neuroscience Research Group, Central European Institute of Technology - CEITEC, Masaryk University, Brno, Czech Republic.
First Department of Neurology, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Sci Rep. 2022 Dec 1;12(1):20754. doi: 10.1038/s41598-022-25016-5.
Transcranial direct current stimulation (tDCS) has the potential to modulate cognitive training in healthy aging; however, results from various studies have been inconsistent. We hypothesized that inter-individual differences in baseline brain state may contribute to the varied results. We aimed to explore whether baseline resting-state dynamic functional connectivity (rs-dFC) and/or conventional resting-state static functional connectivity (rs-sFC) may be related to the magnitude of cognitive aftereffects of tDCS. To achieve this aim, we used data from our double-blind randomized sham-controlled cross-over tDCS trial in 25 healthy seniors in which bifrontal tDCS combined with cognitive training had induced significant behavioral aftereffects. We performed a backward regression analysis including rs-sFC/rs-dFC measures to explain the variability in the magnitude of tDCS-induced improvements in visual object-matching task (VOMT) accuracy. Rs-dFC analysis revealed four rs-dFC states. The occurrence rate of a rs-dFC state 4, characterized by a high correlation between the left fronto-parietal control network and the language network, was significantly associated with tDCS-induced VOMT accuracy changes. The rs-sFC measure was not significantly associated with the cognitive outcome. We show that flexibility of the brain state representing readiness for top-down control of object identification implicated in the studied task is linked to the tDCS-enhanced task accuracy.
经颅直流电刺激（tDCS）有潜力调节健康老年人的认知训练；然而，各项研究的结果并不一致。我们推测，个体间基线脑状态的差异可能导致了结果的不同。我们旨在探究基线静息态动态功能连接（rs-dFC）和/或传统静息态静态功能连接（rs-sFC）是否可能与tDCS的认知后效应程度相关。为实现这一目标，我们使用了来自我们对25名健康老年人进行的双盲随机假对照交叉tDCS试验的数据，在该试验中，双额叶tDCS联合认知训练产生了显著的行为后效应。我们进行了向后回归分析，包括rs-sFC/rs-dFC测量，以解释tDCS诱导的视觉物体匹配任务（VOMT）准确性提高程度的变异性。rs-dFC分析揭示了四种rs-dFC状态。以左额顶叶控制网络与语言网络之间高度相关为特征的rs-dFC状态4的发生率与tDCS诱导的VOMT准确性变化显著相关。rs-sFC测量与认知结果无显著关联。我们表明，在所研究任务中代表对物体识别进行自上而下控制准备状态的脑状态灵活性与tDCS增强的任务准确性相关。
