Aberg M, Arfors K E, Bergentz S E
Acta Chir Scand. 1977;143(7-8):417-9.
The in vivo effect of dextran 70 on Factor VIII (antihemophilic factor) and thrombus stability has been studied in human volunteers after infusion at various rates. Varying the infusion time of dextran from 15 minutes to 2 hours did not result in any differences in the concentrations of dextran, fibrinogen and hematocrit, thus indicating similar degrees of hemodilution. Nor were any differences found in the effect of dextran on Factor VIII and thrombus stability. With regard to the antithrombotic function of dextran by hemodilution and effect on Factor VIII, there does not seem to be any advantage in giving dextran rapidly. This information could be of value in the treatment of elderly patients, for whom thrombosis prophylaxis is especially indicated and whose tolerance for hypervolemia is limited.
在人类志愿者中，已研究了不同输注速率下右旋糖酐70对凝血因子VIII（抗血友病因子）和血栓稳定性的体内作用。将右旋糖酐的输注时间从15分钟改变至2小时，并未导致右旋糖酐、纤维蛋白原和血细胞比容浓度出现任何差异，因此表明存在相似程度的血液稀释。右旋糖酐对凝血因子VIII和血栓稳定性的作用也未发现任何差异。关于右旋糖酐通过血液稀释的抗血栓形成功能及其对凝血因子VIII的作用，快速输注右旋糖酐似乎并无任何优势。该信息对于老年患者的治疗可能具有价值，因为老年患者尤其需要进行血栓预防，且其对血容量过多的耐受性有限。
