右旋糖酐对凝血因子VIII（抗血友病因子）和血小板功能的影响。
Effect of dextran on factor VIII (antihemophilic factor) and platelet function.
作者信息
Aberg M, Hedner U, Bergentz S E
出版信息
Ann Surg. 1979 Feb;189(2):243-7. doi: 10.1097/00000658-197902000-00017.
Abstract
Three different properties of factor VIII (antihemophilic globulin) were studied after infusion of 500 ml of six per cent Dextran 70 to healthy volunteers. This dose caused no change in the factor VIII coagulant activity while there was a significant but temporary decrease of factor VIII related antigen. The Ristocetin induced platelet aggregation analysed with native as well as with formalin-fixed platelets, also decreased significantly. The maximal decrease was found a few hours after the infusion. The decrease was seen only if Dextran was infused in vivo and not if Dextran was added to blood in vitro. The dysfunction of factor VIII caused by Dextran resembles that found in one variant of von Willebrand's disease. This finding probably explains the platelet function inhibiting properties of Dextran, and may be of significance for its antithrombotic effects.
摘要
在向健康志愿者输注500毫升6%的右旋糖酐70后，对凝血因子VIII（抗血友病球蛋白）的三种不同特性进行了研究。该剂量未引起凝血因子VIII凝血活性的变化，而凝血因子VIII相关抗原却出现了显著但短暂的下降。用天然以及福尔马林固定的血小板分析的瑞斯托霉素诱导的血小板聚集也显著降低。输注后数小时出现最大降幅。仅在体内输注右旋糖酐时才出现下降，而在体外将右旋糖酐添加到血液中时则未出现下降。右旋糖酐引起的凝血因子VIII功能障碍类似于在血管性血友病的一种变体中发现的情况。这一发现可能解释了右旋糖酐抑制血小板功能的特性，并且可能对其抗血栓形成作用具有重要意义。
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本文引用的文献
1
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Thromb Diath Haemorrh. 1962 Nov 15;8:297-310.
2
3
Suppressive effect of dextran on platelet adhesiveness.右旋糖酐对血小板黏附性的抑制作用。
Thromb Diath Haemorrh. 1966 Dec 1;16(3):384-94.
4
Determination of alpha-2-macroglobulin as trypsin-protein esterase.将α-2-巨球蛋白测定为胰蛋白酶-蛋白质酯酶。
Clin Chim Acta. 1966 Oct;14(4):493-501. doi: 10.1016/0009-8981(66)90037-4.
5
Counteraction of platelet activity at sites of laser-induced endothelial trauma.激光诱导内皮损伤部位血小板活性的对抗作用。
Br Med J. 1968 Nov 16;4(5628):430-1. doi: 10.1136/bmj.4.5628.430.
6
Crossed immunoelectrophoresis.交叉免疫电泳
Scand J Clin Lab Invest Suppl. 1972;124:39-47. doi: 10.3109/00365517209102749.
7
Effect of dextran infusion on the adenosine diphosphate induced adhesiveness and the spreading capacity of human blood platelets.右旋糖酐输注对二磷酸腺苷诱导的人血小板黏附性及铺展能力的影响。
Thromb Diath Haemorrh. 1966 May 15;15(3):451-6.
8
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J Biol Chem. 1973 Jun 10;248(11):3946-55.
9
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Haemostasis. 1974;3(4):237-46. doi: 10.1159/000214059.
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