From the Department of Radiation Medicine and Applied Sciences, UC San Diego, Moores Cancer Center, La Jolla, CA.
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI.
Cancer J. 2021;27(5):353-363. doi: 10.1097/PPO.0000000000000546.
Gliomas are the most common primary brain cancer, yet are extraordinarily challenging to treat because they can be aggressive and infiltrative, locally recurrent, and resistant to standard treatments. Furthermore, the treatments themselves, including radiation therapy, can affect patients' neurocognitive function and quality of life. Noninvasive imaging is the standard of care for primary brain tumors, including diagnosis, treatment planning, and monitoring for treatment response. This article explores the ways in which advanced imaging has and will continue to transform radiation treatment for patients with gliomas, with a focus on cognitive preservation and novel biomarkers, as well as precision radiotherapy and treatment adaptation. Advances in novel imaging techniques continue to push the field forward, to more precisely guided treatment planning, radiation dose escalation, measurement of therapeutic response, and understanding of radiation-associated injury.
脑胶质瘤是最常见的原发性脑癌，但治疗极具挑战性，因为它们可能具有侵袭性和浸润性、局部复发和对标准治疗有抗性。此外，治疗本身，包括放射治疗，会影响患者的神经认知功能和生活质量。非侵入性成像技术是原发性脑肿瘤的标准护理方法，包括诊断、治疗计划以及监测治疗反应。本文探讨了先进的成像技术如何已经并将继续改变脑胶质瘤患者的放射治疗，重点关注认知保护和新型生物标志物以及精确放疗和治疗适应。新型成像技术的进步不断推动该领域向前发展，以实现更精确的治疗计划、放射剂量升级、治疗反应的测量以及对放射相关损伤的理解。
