Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia and Insitut de Biomedicina (IBUB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain.
Cells. 2021 Sep 8;10(9):2362. doi: 10.3390/cells10092362.
Eukaryotic genomes are packaged into high-order chromatin structures organized in discrete territories inside the cell nucleus, which is surrounded by the nuclear envelope acting as a barrier. This chromatin organization is complex and dynamic and, thus, determining the spatial and temporal distribution and folding of chromosomes within the nucleus is critical for understanding the role of chromatin topology in genome function. Primarily focusing on the regulation of gene expression, we review here how the genome of is organized into the cell nucleus, from small scale histone-DNA interactions to chromosome and lamina interactions in the nuclear space.
真核生物基因组被包装成高级染色质结构，这些结构在细胞核内离散的区域组织，细胞核被核膜包围，充当屏障。这种染色质组织是复杂和动态的，因此，确定染色体在细胞核内的空间和时间分布和折叠对于理解染色质拓扑在基因组功能中的作用至关重要。本文主要关注基因表达的调控，我们在这里回顾了 如何将基因组组织到细胞核中，从小尺度的组蛋白-DNA 相互作用到染色体和核层在核空间中的相互作用。
