Sewerynek E, Lewiński A, Konopacki J, Pawlikowski M, Lewińska M K
Res Exp Med (Berl). 1986;186(1):1-4. doi: 10.1007/BF01851827.
The influence of an intracerebroventricular (i.c.v.) injection of prostaglandin E2 (PGE2) on the mitotic activity of the rat anterior pituitary was investigated. It was found that i.c.v. PGE2 (3 micrograms/20 microliters) resulted in a significant decrease of the mitotic activity in the anterior pituitary. This drop involved mainly chromophobic cells. No mitoses were found in acidophilic cells either in controls or in PGE2-treated rats. It is suggested that PGE2 may release an unidentified hypothalamic factor which inhibits the cell proliferation of the anterior pituitary.
研究了脑室内注射前列腺素E2（PGE2）对大鼠垂体前叶有丝分裂活性的影响。发现脑室内注射PGE2（3微克/20微升）导致垂体前叶有丝分裂活性显著降低。这种下降主要涉及嫌色细胞。在对照组和PGE2处理的大鼠中，嗜酸性细胞均未发现有丝分裂。提示PGE2可能释放一种未知的下丘脑因子，该因子抑制垂体前叶细胞增殖。
