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包含用于药物载体和骨再生的工程微通道的多孔合成骨移植物

Multiple Porous Synthetic Bone Graft Comprising EngineeredMicro-Channel for Drug Carrier and Bone Regeneration.

作者信息

Bae Chun-Sik, Kim Seung-Hyun, Ahn Taeho, Kim Yeonji, Kim Se-Eun, Kang Seong-Soo, Kwon Jae-Sung, Kim Kwang-Mahn, Kim Sahng-Gyoon, Oh Daniel

机构信息

College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea.

OsteoGene Bio, 75 Oak Street, Norwood, NJ 07648, USA.

出版信息

Materials (Basel). 2021 Sep 15;14(18):5320. doi: 10.3390/ma14185320.

DOI:10.3390/ma14185320
PMID:34576544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8471906/
Abstract

Due to high demand but limited supply, there has been an increase in the need to replace autologous bone grafts with alternatives that fulfill osteogenic requirements. In this study, two different types of bone grafts were tested for their drug carrying abilities along with their osteogenic properties. Two different types of alendronate-loaded bone grafts, Bio-Oss (bovine bone graft) and InRoad (biphasic synthetic bone graft) were observed to see how different concentrations of alendronate would affect the sustained release to enhance osteogenesis. In this study, defected ovariectomize-induced osteoporotic rat calvarias were observed for 28 days with three different concentrations of alendronate (0 mg, 1 mg, 5 mg) for both Bio-Oss and InRoad. A higher concentration (5 mg) allowed for a more controlled and sustained release throughout the 28-day comparison to those of lower concentrations (0 mg, 1 mg). When comparing Bio-Oss and InRoad through histology and Micro-CT, InRoad showed higher enhancement in osteogenesis. Through this study, it was observed that alendronate not only brings out robust osteogenesis with InRoad bone grafts, but also enhances bone regeneration in an alendronate-concentration-dependent manner. The combination of higher concentration of alendronate and multiple porous bone graft containing internal micro-channel structure of InRoad resulted in higher osteogenesis with a sustained release of alendronate.

摘要

由于需求高但供应有限，用满足成骨要求的替代品替代自体骨移植的需求有所增加。在本研究中，测试了两种不同类型的骨移植材料的载药能力及其成骨特性。观察了两种不同类型的载阿仑膦酸钠骨移植材料，即Bio-Oss（牛骨移植材料）和InRoad（双相合成骨移植材料），以了解不同浓度的阿仑膦酸钠如何影响其缓释以增强成骨作用。在本研究中，对去卵巢诱导的骨质疏松大鼠颅骨缺损模型观察28天，Bio-Oss和InRoad均设置三种不同浓度的阿仑膦酸钠（0毫克、1毫克、5毫克）。与较低浓度（0毫克、1毫克）相比，较高浓度（5毫克）在整个28天内实现了更可控和持续的释放。通过组织学和显微CT比较Bio-Oss和InRoad时，InRoad在成骨方面表现出更高的增强效果。通过本研究观察到，阿仑膦酸钠不仅能使InRoad骨移植材料产生强大的成骨作用，还能以阿仑膦酸钠浓度依赖的方式促进骨再生。较高浓度的阿仑膦酸钠与具有InRoad内部微通道结构的多孔骨移植材料相结合，可实现更高的成骨作用，并使阿仑膦酸钠持续释放。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/5850a26907e1/materials-14-05320-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/2ad3c7e4dc42/materials-14-05320-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/18a448d17d5c/materials-14-05320-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/d9877f050507/materials-14-05320-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/dd94bb5ad9f0/materials-14-05320-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/01c69499f6a9/materials-14-05320-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/7c8394d4b898/materials-14-05320-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/031969e00707/materials-14-05320-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/5850a26907e1/materials-14-05320-g008a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/2ad3c7e4dc42/materials-14-05320-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/18a448d17d5c/materials-14-05320-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/d9877f050507/materials-14-05320-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/dd94bb5ad9f0/materials-14-05320-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/01c69499f6a9/materials-14-05320-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/7c8394d4b898/materials-14-05320-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/031969e00707/materials-14-05320-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a566/8471906/5850a26907e1/materials-14-05320-g008a.jpg

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