Barbieri R L, Niloff J M, Bast R C, Scaetzl E, Kistner R W, Knapp R C
Fertil Steril. 1986 May;45(5):630-4. doi: 10.1016/s0015-0282(16)49333-7.
CA-125 is a high-molecular-weight glycoprotein that is expressed on the cell surface of some derivatives of embryonic coelomic epithelium. Based on results of an immunoradiometric assay developed to detect CA-125 in peripheral blood, 82% of patients with ovarian cancer and less than 1% of apparently healthy controls have elevated peripheral blood levels of CA-125. Because endometriotic lesions are likely to be derivatives of embryonic coelomic epithelium, the authors investigated serum CA-125 levels in patients with endometriosis. Preoperative serum CA-125 concentrations were measured in 147 patients undergoing diagnostic laparoscopy or laparotomy. Serum CA-125 concentrations were elevated in patients with stage III or IV endometriosis, compared with controls with negative diagnostic laparoscopies (66.5 +/- 14.5 versus 8.20 +/- 0.59 U/ml, mean +/- standard error of the mean; P less than 0.001). Fifty-four percent of patients with stage III or IV endometriosis and 0% of the controls had CA-125 levels greater than 35 U/ml. Occasional patients with stage II endometriosis (13%), leiomyomata uteri (14%), and chronic pelvic inflammatory disease (5%) also had serum CA-125 concentrations greater than 35 U/ml. Immunocytochemical techniques demonstrated the presence of CA-125 on the cell surface of endometriotic lesions.
CA - 125是一种高分子量糖蛋白，在胚胎体腔上皮的一些衍生物的细胞表面表达。基于为检测外周血中CA - 125而开发的免疫放射分析结果，82%的卵巢癌患者外周血CA - 125水平升高，而明显健康的对照组中这一比例不到1%。由于子宫内膜异位病变可能是胚胎体腔上皮的衍生物，作者研究了子宫内膜异位症患者的血清CA - 125水平。对147例行诊断性腹腔镜检查或剖腹手术的患者术前测定血清CA - 125浓度。与诊断性腹腔镜检查阴性的对照组相比，III期或IV期子宫内膜异位症患者的血清CA - 125浓度升高（分别为66.5±14.5和8.20±0.59 U/ml，均值±均值标准误；P<0.001）。III期或IV期子宫内膜异位症患者中有54%的CA - 125水平大于35 U/ml，而对照组中这一比例为0%。偶尔也有II期子宫内膜异位症患者（13%）、子宫肌瘤患者（14%）和慢性盆腔炎患者（5%）的血清CA - 125浓度大于35 U/ml。免疫细胞化学技术显示子宫内膜异位病变的细胞表面存在CA - 125。
