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姜,一种治疗痴呆症的可能候选药物?

Ginger, a Possible Candidate for the Treatment of Dementias?

机构信息

IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.

出版信息

Molecules. 2021 Sep 21;26(18):5700. doi: 10.3390/molecules26185700.

Abstract

As the human life expectancy increases, age-linked diseases have become more and more frequent. The worldwide increment of dementia cases demands medical solutions, but the current available drugs do not meet all the expectations. Recently the attention of the scientific community was attracted by natural compounds, used in ancient medicine, known for their beneficial effects and high tolerability. This review is focused on Ginger () and explore its properties against Alzheimer's Disease and Vascular Dementia, two of the most common and devastating forms of dementia. This work resumes the beneficial effects of Ginger compounds, tested in computational in vitro and in vivo models of Alzheimer's Disease and Vascular Dementia, along with some human tests. All these evidences suggest a potential role of the compounds of ginger not only in the treatment of the disease, but also in its prevention.

摘要

随着人类预期寿命的增加,与年龄相关的疾病变得越来越频繁。全球痴呆病例的增加需要医疗解决方案,但目前可用的药物并不能满足所有期望。最近,科学界的注意力被用于古代医学的天然化合物所吸引,这些化合物以其有益的效果和高耐受性而闻名。本综述重点介绍姜(),并探讨其对阿尔茨海默病和血管性痴呆的作用,这两种痴呆症是最常见和最具破坏性的形式之一。这项工作总结了姜化合物在阿尔茨海默病和血管性痴呆的计算体外和体内模型以及一些人体试验中的有益作用。所有这些证据表明,姜的化合物不仅在疾病的治疗中,而且在疾病的预防中都具有潜在的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3492/8470323/66b7ce8eea62/molecules-26-05700-g001.jpg

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