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涂有I型胶原蛋白的金纳米颗粒及其在人皮肤成纤维细胞中的伤口愈合活性。

Gold nanoparticles coated with collagen-I and their wound healing activity in human skin fibroblast cells.

作者信息

Poomrattanangoon Sasiprapa, Pissuwan Dakrong

机构信息

Materials Science and Engineering Program, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

Nanobiotechnology and Nanobiomaterials Research Laboratory, School of Materials Science and Innovation, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

出版信息

Heliyon. 2024 Jun 20;10(13):e33302. doi: 10.1016/j.heliyon.2024.e33302. eCollection 2024 Jul 15.

DOI:10.1016/j.heliyon.2024.e33302
PMID:39035490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11259839/
Abstract

The slow wound healing process has become a major health problem. Gold nanoparticles AuNPs have been used in various biomedical applications because of their unique properties. Type I collagen (Collagen-I) is a protein and be the most abundant type of collagen. This type of collagen can help the surrounding structure to maintain its rigidity. In this study, we stabilized the surface of AuNPs using Collagen-I (Collagen-I@AuNPs) and investigated the effect of Collagen-I@AuNPs on wound healing. The evaluation of inflammatory cytokine secretion, which were interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α), was performed. We found that Collagen-I@AuNPs reduced the levels of IL-6 and TNF-α in scratched human skin fibroblast (HSF) cells. Furthermore, Collagen-I@AuNPs induced the expression of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF), which are key growth factors involved in wound healing. This results in enhanced wound closure. In addition, Collagen-I@AuNPs were not toxic to HSF cells and facilitated the cellular uptake of particles inside HSF cells. Therefore, Collagen-I@AuNPs is a promising candidate for wound healing enhancement.

摘要

伤口愈合缓慢已成为一个主要的健康问题。金纳米颗粒（AuNPs）因其独特的性质已被用于各种生物医学应用中。I型胶原蛋白（Collagen-I）是一种蛋白质，也是最丰富的胶原蛋白类型。这种类型的胶原蛋白可以帮助周围结构保持其刚性。在本研究中，我们使用Collagen-I稳定AuNPs的表面（Collagen-I@AuNPs），并研究了Collagen-I@AuNPs对伤口愈合的影响。对炎症细胞因子分泌进行了评估，这些细胞因子是白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）。我们发现Collagen-I@AuNPs降低了划痕人皮肤成纤维细胞（HSF）中IL-6和TNF-α的水平。此外，Collagen-I@AuNPs诱导了碱性成纤维细胞生长因子（bFGF）和血管内皮生长因子（VEGF）的表达，这两种因子是伤口愈合中关键的生长因子。这导致伤口闭合增强。此外，Collagen-I@AuNPs对HSF细胞无毒，并促进了HSF细胞内颗粒的细胞摄取。因此，Collagen-I@AuNPs是增强伤口愈合的一个有前途的候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e7/11259839/7de7ec232661/gr8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e7/11259839/231a74f094b6/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e7/11259839/7de7ec232661/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e7/11259839/5c9311c5424c/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e7/11259839/fff97bb7098e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e7/11259839/1a278a4f1ef1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e7/11259839/52e66d6ef96e/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e7/11259839/3e90a4e19f6f/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e7/11259839/dcfe421e907e/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e7/11259839/53a5ed05470d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e7/11259839/231a74f094b6/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25e7/11259839/7de7ec232661/gr8.jpg

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