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在低能生物医学回旋加速器上用氟-18杂交生产锝-99m和锝-101

Hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron.

作者信息

Johnstone Erik V, Mayordomo Natalia, Mausolf Edward J

机构信息

Innovative Fuel Solutions, LLC, Las Vegas, Nevada USA.

Institute of Resource Ecology, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.

出版信息

EPJ Tech Instrum. 2023;10(1):1. doi: 10.1140/epjti/s40485-023-00089-2. Epub 2023 Feb 10.

DOI:10.1140/epjti/s40485-023-00089-2
PMID:36817092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9913010/
Abstract

New modes of production and supply of short-lived radioisotopes using accelerators are becoming attractive alternatives to the use of nuclear reactors. In this study, the use of a compact accelerator neutron source (CANS) was implemented to explore the production of Tc and Tc. Irradiations were performed with neutrons generated from a 16.5 MeV cyclotron utilising the O(, )F reaction during routine F-fluorodeoxyglucose (FDG) production in a commercial radiopharmacy. Natural molybdenum targets in metal form were employed for the production of several Tc isotopes interest via (, ) reactions on Mo and Mo. The production of Tc and Tc under these conditions is considered and discussed.

摘要

利用加速器生产和供应短寿命放射性同位素的新模式正成为使用核反应堆的有吸引力的替代方案。在本研究中，采用紧凑型加速器中子源（CANS）来探索锝和锝的生产。在商业放射性药物生产机构常规生产F-氟脱氧葡萄糖（FDG）期间，利用16.5 MeV回旋加速器产生的中子，通过O（，）F反应进行辐照。采用金属形式的天然钼靶，通过对钼和钼的（，）反应来生产几种感兴趣的锝同位素。对这些条件下锝和锝的生产进行了考虑和讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d96/9913010/06c7c2ae8a43/40485_2023_89_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d96/9913010/b40cd71334f4/40485_2023_89_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d96/9913010/75ad64ae90a3/40485_2023_89_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d96/9913010/b67ff485f717/40485_2023_89_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d96/9913010/c2e4dadac62d/40485_2023_89_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d96/9913010/98cfd97bae11/40485_2023_89_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d96/9913010/06c7c2ae8a43/40485_2023_89_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d96/9913010/b40cd71334f4/40485_2023_89_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d96/9913010/75ad64ae90a3/40485_2023_89_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d96/9913010/b67ff485f717/40485_2023_89_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d96/9913010/c2e4dadac62d/40485_2023_89_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d96/9913010/98cfd97bae11/40485_2023_89_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d96/9913010/06c7c2ae8a43/40485_2023_89_Fig6_HTML.jpg

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Pharmaceuticals (Basel). 2021 Aug 29;14(9):875. doi: 10.3390/ph14090875.
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Lymphat Res Biol. 2021 Apr;19(2):134-140. doi: 10.1089/lrb.2020.0063. Epub 2020 Sep 28.
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Characterization of the neutron flux during production of F at a medical cyclotron and evaluation of the incidental neutron spectrum for neutron damage studies.
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Source term calculation and validation for F-production with a cyclotron for medical applications at HZDR.德国亥姆霍兹重离子研究中心用于医学应用的回旋加速器中F产生的源项计算与验证。
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