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基于聚(乙二醇)甲基醚甲基丙烯酸酯的水凝胶和二氧化铈纳米颗粒作为眼科镜片材料

Poly (Ethylene Glycol) Methyl Ether Methacrylate-Based Hydrogel and Cerium(IV) Oxide Nanoparticles as Ophthalmic Lens Material.

作者信息

Lee Min-Jae, Park Seon-Young, Sung A-Young

机构信息

Department of Optometry, Jeju Tourism University, Jeju 63063, Korea.

Department of Optometry & Vision Science, Daegu Catholic University, Gyeongsan 38430, Korea.

出版信息

Micromachines (Basel). 2021 Sep 16;12(9):1111. doi: 10.3390/mi12091111.

Abstract

The functional hydrogel lens containing 2-hydroxyethylmethacrylate (HEMA) was manufactured by thermal polymerization. The physical properties of the produced hydrogel lens were measured and analyzed. In this study, HEMA, ethylene glycol dimethacrylate (EGDMA), and azobisisobutyronitrile (AIBN) were used for thermal copolymerization. Additionally, poly (ethylene glycol) methyl ether methacrylate (PEGMEMA), 3-(Triethoxysilyl) propyl isocyanate (TEPI), and cerium(Ⅳ) oxide nanoparticles were used as additives to make a functional hydrogel lens. The mixture was heated at 100 °C for 90 min to produce the hydrogel ophthalmic lens by the cast mold method. The resulting physical properties showed that the water content and refractive index of the sample were in the ranges of 38.0642.11% and 1.4261.436, respectively. The addition of cerium oxide nanoparticles lowered the contact angle and allowed the hydrogel lens to block UV light. The tensile strength was also improved by 52.13% through cerium oxide nanoparticles, and up to 123.4% by using TEPI. Based on the results of this study, the produced ophthalmic lens is suitable for durable, UV-blocking high-performance lenses.

摘要

含甲基丙烯酸羟乙酯(HEMA)的功能性水凝胶镜片通过热聚合制备。对制得的水凝胶镜片的物理性能进行了测量和分析。在本研究中,甲基丙烯酸羟乙酯(HEMA)、乙二醇二甲基丙烯酸酯(EGDMA)和偶氮二异丁腈(AIBN)用于热共聚。此外,聚(乙二醇)甲基醚甲基丙烯酸酯(PEGMEMA)、3-(三乙氧基甲硅烷基)丙基异氰酸酯(TEPI)和氧化铈纳米颗粒用作添加剂以制备功能性水凝胶镜片。将混合物在100℃加热90分钟,通过浇铸模具法制备水凝胶眼科镜片。所得物理性能表明,样品的含水量和折射率分别在38.06%至42.11%和1.426至1.436的范围内。氧化铈纳米颗粒的添加降低了接触角,并使水凝胶镜片能够阻挡紫外线。通过氧化铈纳米颗粒,拉伸强度也提高了52.13%,使用TEPI时提高了123.4%。基于本研究结果,制得的眼科镜片适用于耐用、防紫外线的高性能镜片。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89cd/8471772/3d7cc018b18d/micromachines-12-01111-g001.jpg

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