State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Viruses. 2021 Aug 26;13(9):1698. doi: 10.3390/v13091698.
Avian infectious bronchitis virus (IBV) is an important gammacoronavirus. The virus is highly contagious, can infect chickens of all ages, and causes considerable economic losses in the poultry industry worldwide. In the last few decades, numerous studies have been published regarding pathogenicity, vaccination, and host immunity-virus interaction. In particular, innate immunity serves as the first line of defense against invasive pathogens and plays an important role in the pathogenetic process of IBV infection. This review focuses on fundamental aspects of host innate immune responses after IBV infection, including identification of conserved viral structures and different components of host with antiviral activity, which could provide useful information for novel vaccine development, vaccination strategies, and intervention programs.
禽传染性支气管炎病毒（IBV）是一种重要的γ冠状病毒。该病毒具有高度传染性，可感染所有年龄段的鸡，给全球家禽业造成了巨大的经济损失。在过去几十年中，已有大量关于致病性、疫苗接种和宿主免疫-病毒相互作用的研究发表。特别是，先天免疫作为抵御入侵病原体的第一道防线，在 IBV 感染的发病机制过程中起着重要作用。本综述重点介绍了 IBV 感染后宿主固有免疫反应的基本方面，包括鉴定具有抗病毒活性的保守病毒结构和宿主的不同成分，这可为新型疫苗开发、免疫接种策略和干预计划提供有用信息。
