Equine Medicine and Reproduction, Centre for Clinical Veterinary Medicine, Faculty of Veterinary Medicine, Ludwig-Maximilians University Munich, Veterinärstraße 13, 80539 Munich, Germany.
Institute for Veterinary Disease Control Mödling, Austrian Agency for Health and Food Safety GmbH (AGES), IVET, 2340 Mödling, Austria.
Viruses. 2021 Sep 6;13(9):1775. doi: 10.3390/v13091775.
A final diagnosis in a horse with clinical signs of encephalopathy can be challenging despite the use of extensive diagnostics. Clinical signs are often not pathognomonic and need to be interpreted in combination with (specific) laboratory results and epidemiological data of the geographical region of the origin of the case(s). Here we describe the diagnostic pathway of tick-borne encephalitis virus infection in two horses using established molecular diagnostic methods and a novel in situ hybridization technique to differentiate between regionally important/emerging diseases for central Europe: (i) hepatoencephalopathy, (ii) Borna disease virus, and (iii) West Nile virus infections.
尽管使用了广泛的诊断方法，但是对于有脑病临床症状的马，最终诊断仍然具有挑战性。临床症状通常没有特征性，需要结合（特定的）实验室结果和病例来源地区的流行病学数据进行解释。在这里，我们使用已建立的分子诊断方法和一种新的原位杂交技术来描述两例蜱传脑炎病毒感染的诊断途径，以区分中欧地区重要/新兴疾病：（i）肝性脑病，（ii）博纳病病毒和（iii）西尼罗河病毒感染。
