Shono Hitoshi, Tsutsumi Rie, Beppu Kana, Matsushima Rina, Watanabe Suzuno, Fujimoto Chisa, Kanamura Ryo, Ohnishi Hiroki, Kondo Eiji, Azuma Takahiro, Sato Go, Kawai Misako, Matsumoto Hideki, Kitamura Yoshiaki, Sakaue Hiroshi, Takeda Noriaki
Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan.
Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University, Tokushima 770-8503, Japan.
Nutrients. 2021 Aug 24;13(9):2921. doi: 10.3390/nu13092921.
(Background) We investigated the effect of dietary supplementation with monosodium glutamate (MSG) on chemotherapy-induced downregulation of the T1R3 taste receptor subunit expression in the tongue of patients with advanced head and neck cancer. (Methods) Patients undergoing two rounds of chemoradiotherapy were randomly allocated to a control or intervention group (dietary supplementation with MSG at 2.7 g/day during the second round of chemotherapy). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative polymerase chain reaction analysis. Dysgeusia was assessed with a visual analog scale and daily energy intake was evaluated. (Results) T1R3 expression levels in the tongue, taste sensitivity, and daily energy intake were significantly reduced after the first round of chemotherapy compared with before treatment. Furthermore, these parameters significantly decreased after the second round of chemotherapy, but the extent of decrease was significantly attenuated in the MSG group compared with the control group. (Conclusions) MSG supplementation suppresses chemotherapy-induced dysgeusia, possibly due to the inhibition of the T1R3-containing taste receptor downregulation in the tongue, thereby increasing energy intake in patients with advanced head and neck cancer.
（背景）我们研究了补充味精（MSG）饮食对晚期头颈癌患者化疗引起的舌中T1R3味觉受体亚基表达下调的影响。（方法）接受两轮放化疗的患者被随机分为对照组或干预组（在第二轮化疗期间每天补充2.7克味精饮食）。通过定量聚合酶链反应分析评估舌中鲜味和甜味受体共同的亚基T1R3的相对表达。用视觉模拟量表评估味觉障碍，并评估每日能量摄入量。（结果）与治疗前相比，第一轮化疗后舌中T1R3表达水平、味觉敏感性和每日能量摄入量显著降低。此外，第二轮化疗后这些参数显著下降，但与对照组相比，味精组下降程度显著减轻。（结论）补充味精可抑制化疗引起的味觉障碍，可能是由于抑制了舌中含T1R3味觉受体的下调，从而增加晚期头颈癌患者的能量摄入。
