Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt.
Department of Pharmacognosy, Faculty of Pharmacy, Port Said University, 42526 Port Said, Egypt.
Mini Rev Med Chem. 2022;22(8):1152-1196. doi: 10.2174/1389557521666210927152249.
Marine organisms are recognized as a rich source of bioactive secondary metabolites. The remarkable abundance and diversity of bioactive small molecules isolated from soft corals displayed their essential role in drug discovery for human diseases. Sterols and terpenes, particularly cembranolides, 14-membered cyclic diterpene, demonstrated numerous biological activities, such as antitumor, antimicrobial, antiviral, antidiabetic, anti-osteoporosis and anti-inflammatory. Accordingly, continuous investigation of marine soft corals leads the way to discover a plentiful number of chemical diverse natural products with various biological potentials for prospective pharmaceutical industrial applications. Such review affords plenary inspection of the total secondary metabolites isolated from the Sinularia, from 2008 until 2020, besides their natural sources as well as bioactivities whenever possible.
海洋生物被认为是生物活性次生代谢产物的丰富来源。从软珊瑚中分离出的生物活性小分子的丰富性和多样性表明它们在人类疾病药物发现中具有重要作用。甾醇和萜类化合物，特别是海鞘素，一种 14 元环二萜，表现出多种生物活性，如抗肿瘤、抗菌、抗病毒、抗糖尿病、抗骨质疏松和抗炎。因此，对海洋软珊瑚的持续研究为发现大量具有各种生物潜力的化学多样的天然产物提供了途径，这些天然产物可用于未来的制药工业应用。本综述全面考察了从 2008 年到 2020 年从 sinularia 中分离得到的次生代谢产物的总数，以及它们的天然来源和生物活性（只要有可能）。
