Nishimura K, Kitagawa M, Tomita Y, Kakeya N, Kitao K
Jpn J Antibiot. 1986 Jan;39(1):94-8.
The effect of ceftizoxime suppository (CZX-S), a new rectal preparation of ceftizoxime (CZX), against cecal microflora of mice following consecutive rectal administration was compared with that after subcutaneous administration of CZX. The numbers of aerobic and anaerobic bacteria except Enterobacteriaceae of cecal microflora were not markedly changed by the rectal administration of CZX-S at a dose of 25 mg/kg 3 times daily for 10 days. Although the number of Enterobacteriaceae was decreased, recovery was rapidly observed after completion of the administration period. In the case of subcutaneous administration, a decrease in Enterobacteriaceae was also observed, but this was no more remarkable than that occurring with rectal administration. Moreover, effects on the state of feces, i.e., diarrhea, were not observed in any of the mice. The peak level of CZX in the cecum contents when administered rectally at a dose of 25 mg/kg was 13.8 micrograms/g at 4 hours, while it was less than the determination limit (2.0 micrograms/g) when administered subcutaneously at the same dose.
将头孢唑肟的新型直肠制剂头孢唑肟栓（CZX-S）连续直肠给药后对小鼠盲肠微生物群的影响，与皮下注射头孢唑肟（CZX）后的影响进行了比较。以25mg/kg的剂量每日3次连续直肠给药10天，头孢唑肟栓对盲肠微生物群中除肠杆菌科以外的需氧菌和厌氧菌数量没有明显影响。虽然肠杆菌科数量减少，但在给药期结束后很快观察到其恢复。皮下给药的情况下，也观察到肠杆菌科数量减少，但并不比直肠给药更显著。此外，未在任何小鼠中观察到对粪便状态即腹泻的影响。以25mg/kg的剂量直肠给药时，盲肠内容物中头孢唑肟的峰值水平在4小时时为13.8微克/克，而以相同剂量皮下给药时则低于测定限（2.0微克/克）。
