Yamamoto T, Yasuda J, Tomioka M, Kanao M, Okada H
Jpn J Antibiot. 1986 Jun;39(6):1504-8.
A pharmacokinetic study on ceftizoxime suppository (CZX-S), a new rectal suppository of ceftizoxime (CZX), was carried out in the field of obstetrics and gynecology. Concentrations of CZX after single rectal administrations of a 500 mg dose in peripheral venous serum, uterine arterial serum and internal genital organs of 15 patients who received simple panhysterectomy were examined. Peak levels of CZX in peripheral venous serum were 7.26 to 8.88 micrograms/ml at 30 minutes after the administration. Concentrations of CZX in internal genital organs reached 2.12 to 8.96 micrograms/g at 30 minutes after the administration and then decreased slowly, but still remained at 0.37-3.12 micrograms/g after 4 hours.
在妇产科领域开展了一项关于头孢唑肟栓（CZX - S，一种新型的头孢唑肟（CZX）直肠栓剂）的药代动力学研究。对15例行单纯全子宫切除术的患者单次直肠给予500mg剂量后，检测其外周静脉血清、子宫动脉血清及内生殖器中CZX的浓度。给药后30分钟，外周静脉血清中CZX的峰值水平为7.26至8.88微克/毫升。给药后30分钟，内生殖器中CZX的浓度达到2.12至8.96微克/克，随后缓慢下降，但4小时后仍保持在0.37 - 3.12微克/克。
