School of Pharmacy, Chengdu Medical College, Chengdu, 610500, Sichuan, China.
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, 610041, Sichuan, China.
Anal Bioanal Chem. 2022 Jan;414(2):867-884. doi: 10.1007/s00216-021-03674-0. Epub 2021 Sep 28.
C-reactive protein (CRP), a non-specific acute-phase indicator of inflammation, has been widely recognized for its value in clinical diagnostic applications. With the advancement of testing technologies, there have been many reports on fast, simple, and reliable methods for CRP testing. Among these, the aptamer-based biosensors are the focus and hotspot of research for achieving high-sensitivity analysis of CRP. This review summarizes the progress of in vitro aptamer screening for CRP and the recent advances in aptamer-based CRP sensor applications, thus developing insight for the new CRP aptasensor design strategy.
C-反应蛋白（CRP）是一种非特异性炎症急性期标志物，其在临床诊断应用中的价值已得到广泛认可。随着检测技术的进步，已经有很多关于 CRP 快速、简单、可靠检测方法的报道。其中，基于适配体的生物传感器是实现 CRP 高灵敏度分析的研究重点和热点。本文综述了 CRP 的体外适配体筛选进展以及基于适配体的 CRP 传感器应用的最新进展，为新型 CRP 适配体传感器设计策略提供了思路。
