Zhao Yifan, Peng Hongyi, Sun Lingxiang, Tong Jiahui, Cui Chenying, Bai Ziyang, Yan Jingyu, Qin Danlei, Liu Yingyu, Wang Jue, Wu Xiuping, Li Bing
Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, Shanxi, China.
Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, 030001, Shanxi, China.
Mater Today Bio. 2024 Mar 18;26:101032. doi: 10.1016/j.mtbio.2024.101032. eCollection 2024 Jun.
The distinctive three-dimensional architecture, biological functionality, minimal immunogenicity, and inherent biodegradability of small intestinal submucosa extracellular matrix materials have attracted considerable interest and found wide-ranging applications in the domain of tissue regeneration engineering. This article presents a comprehensive examination of the structure and role of small intestinal submucosa, delving into diverse preparation techniques and classifications. Additionally, it proposes approaches for evaluating and modifying SIS scaffolds. Moreover, the advancements of SIS in the regeneration of skin, bone, heart valves, blood vessels, bladder, uterus, and urethra are thoroughly explored, accompanied by their respective future prospects. Consequently, this review enhances our understanding of the applications of SIS in tissue and organ repair and keeps researchers up-to-date with the latest research advancements in this area.
小肠黏膜下层细胞外基质材料独特的三维结构、生物学功能、低免疫原性和固有的生物可降解性引起了广泛关注，并在组织再生工程领域得到了广泛应用。本文全面审视了小肠黏膜下层的结构和作用，深入探讨了多种制备技术和分类。此外，还提出了评估和改性小肠黏膜下层支架的方法。此外，还深入探讨了小肠黏膜下层在皮肤、骨骼、心脏瓣膜、血管、膀胱、子宫和尿道再生方面的进展及其各自的未来前景。因此，本综述增进了我们对小肠黏膜下层在组织和器官修复中应用的理解，并使研究人员了解该领域的最新研究进展。
