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体肌的肌源性收缩为果蝇触角中的血淋巴提供了有节奏的流动动力,并产生了脑脉冲。

Myogenic contraction of a somatic muscle powers rhythmic flow of hemolymph through Drosophila antennae and generates brain pulsations.

机构信息

Department of Biology, University of Iowa, Iowa City, IA 52242, USA.

Neurobiology Section, Division of Biological Sciences, University of California, San Diego, CA 92093, USA.

出版信息

J Exp Biol. 2021 Oct 15;224(20). doi: 10.1242/jeb.242699. Epub 2021 Oct 22.

Abstract

Hemolymph is driven through the antennae of Drosophila melanogaster by the rhythmic contraction of muscle 16 (m16), which runs through the brain. Contraction of m16 results in the expansion of an elastic ampulla, opening ostia and filling the ampulla. Relaxation of the ampullary membrane forces hemolymph through vessels into the antennae. We show that m16 is an auto-active rhythmic somatic muscle. The activity of m16 leads to the rapid perfusion of the antenna by hemolymph. In addition, it leads to the rhythmic agitation of the brain, which could be important for clearing the interstitial space.

摘要

血淋巴通过果蝇的触角被肌肉 16(m16)有节奏地驱动,该肌肉贯穿大脑。m16 的收缩导致弹性壶腹扩张,打开口并填充壶腹。壶腹膜的松弛迫使血淋巴通过血管进入触角。我们表明 m16 是一种自动活跃的节律性体壁肌肉。m16 的活动导致血淋巴快速灌注触角。此外,它还导致大脑有节奏地搅动,这对于清除细胞间隙可能很重要。

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The Brain's Glymphatic System: Current Controversies.大脑的胶状淋巴系统:当前的争议。
Trends Neurosci. 2020 Jul;43(7):458-466. doi: 10.1016/j.tins.2020.04.003. Epub 2020 May 15.
4
The Insect Circulatory System: Structure, Function, and Evolution.昆虫循环系统:结构、功能与演化。
Annu Rev Entomol. 2020 Jan 7;65:121-143. doi: 10.1146/annurev-ento-011019-025003. Epub 2019 Oct 4.
6
On the Morphology of the Drosophila Heart.果蝇心脏的形态学
J Cardiovasc Dev Dis. 2016 Apr 12;3(2):15. doi: 10.3390/jcdd3020015.
7
On the Evolution of the Cardiac Pacemaker.论心脏起搏器的演变
J Cardiovasc Dev Dis. 2017 Apr 27;4(2):4. doi: 10.3390/jcdd4020004.

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