Munera M I, Cuesta F, Abadia A, Vasquez J, Restrepo M
Corporación Investigaciones Biológicas, Medellín, Colombia.
Antimicrob Agents Chemother. 1994 Mar;38(3):632-4. doi: 10.1128/AAC.38.3.632.
Ten patients who had undergone laparotomies for different abdominal pathological conditions were studied to determine the levels of pefloxacin in mesenteric lymph nodes. Each patient was given 400 mg of oral pefloxacin every 12 h for the 3 days prior to surgery. Drug levels in tissue were determined by high-pressure liquid chromatography (reverse phase); the mean +/- standard deviation was 17.1 +/- 11.9 micrograms/g, with a range of 2.12 to 36.6 micrograms/g. This indicates an adequate pefloxacin concentration in lymph nodes and makes the drug a good option for the treatment of conditions in which lymph nodes act as an infection-promoting and/or relapse-favoring factor.
对10例因不同腹部病理状况接受剖腹手术的患者进行研究，以测定肠系膜淋巴结中培氟沙星的水平。在手术前3天，每位患者每12小时口服400毫克培氟沙星。通过高压液相色谱法（反相）测定组织中的药物水平；平均值±标准差为17.1±11.9微克/克，范围为2.12至36.6微克/克。这表明培氟沙星在淋巴结中的浓度足够，使该药物成为治疗淋巴结作为感染促进和/或复发促进因素的疾病的良好选择。
