Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
BMC Microbiol. 2021 Sep 29;21(1):262. doi: 10.1186/s12866-021-02319-7.
This study aimed to determine the frequency of methicillin-resistant Staphylococcus aureus (MRSA), antibiotic resistance patterns, superantigenic toxins profile, and clonality of this pathogen in patients with cancer.
In total, 79 (25.7%) isolates were confirmed as Staphylococcus species, from which 38 (48.1%) isolates were S. aureus, and 29 (76.3%) isolates were confirmed as MRSA. The highest resistance in MRSA strains was seen against ciprofloxacin (86.2%) and erythromycin (82.8%). Teicoplanin, and linezolid were the most effective antibiotics. From all MRSA isolates, 3 strains (10.3%) were resistant to vancomycin with minimum inhibitory concentration values of 128 μg/ml. The prevalence of superantigenic toxins genes was as follows: pvl (10.5%), tsst-1 (36.8%), etA (23.7%), and etB (23.7%). The t14870 spa type with frequency of 39.5% was the most prevalent clone type circulating in the cancer patients.
This study showed the circulating of spa t14870 as the most predominant MRSA clone in cancer patients of southwest Iran. Also, a diverse antibiotic resistance pattern and toxin profiles were seen among MRSA isolates.
本研究旨在确定癌症患者中耐甲氧西林金黄色葡萄球菌（MRSA）的频率、抗生素耐药模式、超抗原毒素谱和该病原体的克隆性。
共鉴定出 79 株（25.7%）葡萄球菌属分离株，其中 38 株（48.1%）为金黄色葡萄球菌，29 株（76.3%）确认为 MRSA。MRSA 菌株对环丙沙星（86.2%）和红霉素（82.8%）的耐药率最高。替考拉宁和利奈唑胺是最有效的抗生素。所有 MRSA 分离株中，有 3 株（10.3%）对万古霉素耐药，最小抑菌浓度值为 128μg/ml。超抗原毒素基因的流行率如下：pvl（10.5%）、tsst-1（36.8%）、etA（23.7%）和 etB（23.7%）。t14870 spa 型的频率为 39.5%，是在伊朗西南部癌症患者中循环的最主要的 MRSA 克隆型。
本研究表明，在伊朗西南部癌症患者中，spa t14870 是最主要的 MRSA 克隆。此外，MRSA 分离株表现出不同的抗生素耐药模式和毒素谱。
