• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

神经递质和电生理变化可能成为诊断情感障碍的生物标志物。

Neurotransmitters and Electrophysiological Changes Might Work as Biomarkers for Diagnosing Affective Disorders.

机构信息

Institute of Brain and Psychological Science, Sichuan Normal University, Chengdu, Sichuan 610000, China.

Department of Psychology, Jiangsu University, Zhenjiang, Jiangsu 212013, China.

出版信息

Dis Markers. 2021 Sep 18;2021:9116502. doi: 10.1155/2021/9116502. eCollection 2021.

DOI:10.1155/2021/9116502
PMID:34589159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8476281/
Abstract

Affective disorders are the leading causes of human disability worldwide; however, the diagnosis is still hard to define, because emotion is the least study subjects in psychology. Recent emotional studies suggest that human emotions are developed from basic emotions, which are evolved for fundamental human lives. . In our previous papers, we suggested that there are three basic emotions: joy, fear, and disgust. . Further tests with event-related potentials (ERP) found that joy, fear, and disgust showed the fastest response compared with other emotions, suggesting that they are fast automatic responses, which confirmed that these three emotions are prototypical emotions. Other basic emotions, anger and sadness, are due to object induced behaviors instead of sensation of object, so they developed secondary to prototypical emotions. Thus, we concluded that only joy, fear, and disgust are prototypical emotions, which can mix into other emotions, like the primary colors. In all, the neural substrates for all emotions, including the affections, are possibly monoamine neuromodulators: joy-dopamine (peptides), fear (anger)-norepinephrine, and disgust-serotonin. We hope these basic emotional studies will offer some neural mechanisms for emotional processing and shed lights on the diagnosis of affective disorders.

摘要

情感障碍是全球导致人类残疾的主要原因;然而,诊断仍然难以定义,因为情感是心理学中研究最少的课题。最近的情感研究表明,人类情感是从基本情感发展而来的,这些基本情感是为人类的基本生活而进化的。在我们之前的论文中,我们提出了有三种基本情感:喜悦、恐惧和厌恶。进一步的事件相关电位 (ERP) 测试发现,喜悦、恐惧和厌恶与其他情感相比表现出最快的反应,这表明它们是快速的自动反应,这证实了这三种情感是典型情感。其他基本情感,如愤怒和悲伤,是由于对象诱导的行为而不是对对象的感觉,因此它们是在典型情感之后发展起来的。因此,我们得出结论,只有喜悦、恐惧和厌恶是典型情感,它们可以混合成其他情感,就像原色一样。总的来说,所有情感的神经基质,包括情感,可能都是单胺神经调质:喜悦-多巴胺(肽)、恐惧(愤怒)-去甲肾上腺素和厌恶-血清素。我们希望这些基本情感研究将为情感处理提供一些神经机制,并为情感障碍的诊断提供一些启示。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a665/8476281/3a216c2517ac/DM2021-9116502.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a665/8476281/4b721b328ff6/DM2021-9116502.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a665/8476281/70c2aa29a68b/DM2021-9116502.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a665/8476281/65a513d1c081/DM2021-9116502.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a665/8476281/417bfd5f7fa8/DM2021-9116502.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a665/8476281/3a216c2517ac/DM2021-9116502.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a665/8476281/4b721b328ff6/DM2021-9116502.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a665/8476281/70c2aa29a68b/DM2021-9116502.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a665/8476281/65a513d1c081/DM2021-9116502.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a665/8476281/417bfd5f7fa8/DM2021-9116502.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a665/8476281/3a216c2517ac/DM2021-9116502.005.jpg

相似文献

1
Neurotransmitters and Electrophysiological Changes Might Work as Biomarkers for Diagnosing Affective Disorders.神经递质和电生理变化可能成为诊断情感障碍的生物标志物。
Dis Markers. 2021 Sep 18;2021:9116502. doi: 10.1155/2021/9116502. eCollection 2021.
2
Perceptual learning and recognition confusion reveal the underlying relationships among the six basic emotions.知觉学习与识别混淆揭示了六种基本情绪之间的潜在关系。
Cogn Emot. 2019 Jun;33(4):754-767. doi: 10.1080/02699931.2018.1491831. Epub 2018 Jun 30.
3
Anxious Personality Traits: Perspectives from Basic Emotions and Neurotransmitters.焦虑型人格特质:来自基本情绪和神经递质的视角
Brain Sci. 2022 Aug 27;12(9):1141. doi: 10.3390/brainsci12091141.
4
Specific respiratory patterns distinguish among human basic emotions.特定的呼吸模式能区分人类的基本情绪。
Int J Psychophysiol. 1991 Aug;11(2):141-54. doi: 10.1016/0167-8760(91)90006-j.
5
Mechanisms for attentional modulation by threatening emotions of fear, anger, and disgust.恐惧、愤怒和厌恶等威胁性情绪对注意力调节的机制。
Cogn Affect Behav Neurosci. 2017 Feb;17(1):198-210. doi: 10.3758/s13415-016-0473-9.
6
Monoamine Neurotransmitters Control Basic Emotions and Affect Major Depressive Disorders.单胺类神经递质控制基本情绪并影响重度抑郁症。
Pharmaceuticals (Basel). 2022 Sep 28;15(10):1203. doi: 10.3390/ph15101203.
7
Dual-Language Testing of Emotional Verbal Fluency: A Closer Look at "Joy," "Sadness," "Fear," "Anger," and "Disgust".情绪性言语流畅性的双语测试:深入探究“喜悦”“悲伤”“恐惧”“愤怒”和“厌恶”
Arch Clin Neuropsychol. 2023 Jan 21;38(1):91-105. doi: 10.1093/arclin/acac054.
8
The emotional side of taking part in a cancer clinical trial.参与癌症临床试验的情感层面。
PLoS One. 2023 Apr 24;18(4):e0284268. doi: 10.1371/journal.pone.0284268. eCollection 2023.
9
Turkish Emotional Word Norms for Arousal, Valence, and Discrete Emotion Categories.土耳其情绪词唤醒度、效价和离散情绪类别常模。
Psychol Rep. 2021 Feb;124(1):188-209. doi: 10.1177/0033294118814722. Epub 2018 Dec 4.
10
Unfolding and dynamics of affect bursts decoding in humans.人类情感爆发的展开和动态解码。
PLoS One. 2018 Oct 30;13(10):e0206216. doi: 10.1371/journal.pone.0206216. eCollection 2018.

引用本文的文献

1
Event-related potential biomarkers in temporal lobe epilepsy: N170, vertex positive potential, late positive potential, and P3 signatures of depression comorbidity.颞叶癫痫中的事件相关电位生物标志物:N170、头顶正电位、晚期正电位以及合并抑郁症的P3特征。
SAGE Open Med. 2025 Apr 27;13:20503121251335468. doi: 10.1177/20503121251335468. eCollection 2025.
2
Retracted: Neurotransmitters and Electrophysiological Changes Might Work as Biomarkers for Diagnosing Affective Disorders.撤回:神经递质和电生理变化可能作为诊断情感障碍的生物标志物。
Dis Markers. 2023 Nov 1;2023:9792838. doi: 10.1155/2023/9792838. eCollection 2023.
3

本文引用的文献

1
Editorial: Stress Induced Neural Changes in Emotional Disorders.社论:情绪障碍中应激诱导的神经变化
Front Psychiatry. 2021 Jun 24;12:710691. doi: 10.3389/fpsyt.2021.710691. eCollection 2021.
2
Emotion and threat detection: The roles of affect and conceptual knowledge.情绪与威胁检测:情感与概念知识的作用。
Emotion. 2022 Dec;22(8):1929-1941. doi: 10.1037/emo0000884. Epub 2021 Jun 3.
3
Emotion Induced Monoamine Neuromodulator Release Affects Functional Neurological Disorders.情绪诱导的单胺神经调节剂释放影响功能性神经障碍。
Eye movements and ERP biomarkers for face processing problems in avoidant attachment-style individuals.
回避型依恋风格个体面部加工问题的眼动和事件相关电位生物标志物
Front Behav Neurosci. 2023 May 19;17:1135909. doi: 10.3389/fnbeh.2023.1135909. eCollection 2023.
4
Opposite effects of estradiol and progesterone on woman's disgust processing.雌二醇和孕酮对女性厌恶情绪处理的相反作用。
Front Psychiatry. 2023 Apr 5;14:1161488. doi: 10.3389/fpsyt.2023.1161488. eCollection 2023.
5
Editorial: New paradigm of attention and attention training: Mechanisms and applications.社论:注意力及注意力训练的新范式:机制与应用
Front Hum Neurosci. 2023 Jan 20;17:1122941. doi: 10.3389/fnhum.2023.1122941. eCollection 2023.
6
Editorial: Natural products and brain energy metabolism: Astrocytes in neurodegenerative diseases Volume II.社论:天然产物与脑能量代谢:神经退行性疾病中的星形胶质细胞 第二卷
Front Pharmacol. 2023 Jan 17;14:1137554. doi: 10.3389/fphar.2023.1137554. eCollection 2023.
7
Monoamine Neurotransmitters Control Basic Emotions and Affect Major Depressive Disorders.单胺类神经递质控制基本情绪并影响重度抑郁症。
Pharmaceuticals (Basel). 2022 Sep 28;15(10):1203. doi: 10.3390/ph15101203.
8
Editorial: Natural products and brain energy metabolism: Astrocytes in neurodegenerative diseases.社论:天然产物与脑能量代谢:神经退行性疾病中的星形胶质细胞
Front Pharmacol. 2022 Oct 3;13:1039904. doi: 10.3389/fphar.2022.1039904. eCollection 2022.
9
Pharmacological and Physiological Correlates of the Bidirectional Fear Phenotype of the Carioca Rats and Other Bidirectionally Selected Lines.卡里奥卡大鼠及其他双向选择品系双向恐惧表型的药理学和生理学相关性。
Curr Neuropharmacol. 2023;21(9):1864-1883. doi: 10.2174/1570159X20666221012121534.
10
Anxious Personality Traits: Perspectives from Basic Emotions and Neurotransmitters.焦虑型人格特质:来自基本情绪和神经递质的视角
Brain Sci. 2022 Aug 27;12(9):1141. doi: 10.3390/brainsci12091141.
Front Cell Dev Biol. 2021 Feb 15;9:633048. doi: 10.3389/fcell.2021.633048. eCollection 2021.
4
Early Life Stress Induced DNA Methylation of Monoamine Oxidases Leads to Depressive-Like Behavior.早期生活压力诱导单胺氧化酶的DNA甲基化导致类似抑郁的行为。
Front Cell Dev Biol. 2020 Sep 8;8:582247. doi: 10.3389/fcell.2020.582247. eCollection 2020.
5
Screening Depressive Disorders With Tree-Drawing Test.用画树测试筛查抑郁症
Front Psychol. 2020 Jun 25;11:1446. doi: 10.3389/fpsyg.2020.01446. eCollection 2020.
6
The Relationship between Insecure Attachment to Depression: Mediating Role of Sleep and Cognitive Reappraisal.不安全依恋与抑郁的关系:睡眠和认知重评的中介作用。
Neural Plast. 2020 Apr 14;2020:1931737. doi: 10.1155/2020/1931737. eCollection 2020.
7
Editorial: Neurotransmitters and Emotions.社论:神经递质与情绪
Front Psychol. 2020 Jan 29;11:21. doi: 10.3389/fpsyg.2020.00021. eCollection 2020.
8
What Basic Emotion Theory Really Says for the Twenty-First Century Study of Emotion.基础情感理论对21世纪情感研究的实际意义。
J Nonverbal Behav. 2019 Jun;43(2):195-201. doi: 10.1007/s10919-019-00298-y. Epub 2019 Feb 13.
9
A Model for Basic Emotions Using Observations of Behavior in .一种基于行为观察的基本情绪模型 。(原文最后不完整,这里根据已有内容尽量完整翻译)
Front Psychol. 2019 Apr 24;10:781. doi: 10.3389/fpsyg.2019.00781. eCollection 2019.
10
The Utility of Event-Related Potentials in Clinical Psychology.事件相关电位在临床心理学中的应用。
Annu Rev Clin Psychol. 2019 May 7;15:71-95. doi: 10.1146/annurev-clinpsy-050718-095457.