Department of Behavioral Health and Nutrition, College of Health Sciences, University of Delaware, Newark, DE 19716, USA.
Food Funct. 2018 Jun 20;9(6):3185-3194. doi: 10.1039/c8fo00468d.
Hypertension and dyslipidemia are major risk factors for cardiovascular disease (CVD). Common treatments for high blood pressure (BP) and dyslipidemia include medications, but there is question as to whether natural sources may be adequate to reduce CVD risk factors. We examined the effects of tart cherry juice on lipid profiles, BP, glucose, insulin, and homeostatic model assessment-insulin resistance (HOMA-IR) in older adults. In this randomized-controlled clinical trial, 17 men and 20 women between the ages of 65-80 years were randomly assigned to consume 480 ml of tart cherry juice or control drink daily for 12 weeks. Control beverages were matched for energy and sugar content. Outcome variables were assessed at baseline and after 12 weeks of tart cherry juice or control drink. Systolic BP and low-density lipoprotein cholesterol (LDL) exhibited treatment × time interaction effects. At the end of the study, participants in the tart cherry group had lower levels of LDL cholesterol (difference of -20.6 with P = 0.001) and total cholesterol (difference of -19.11 with P = 0.01), and higher levels of glucose (difference of 7.94 with P = 0.001), triglycerides (difference of 6.66 with P = 0.01) and BMI (difference of 1.06 with P = 0.02) than in the control group. Neither tart cherry juice nor control significantly altered body weight, high-density lipoprotein cholesterol, diastolic BP, insulin and HOMA-IR. Our findings show that tart cherry juice can lower the levels of systolic BP and LDL cholesterol. However, larger and longer follow-up studies are needed to further assess cardio-protective effects of tart cherry juice.
高血压和血脂异常是心血管疾病（CVD）的主要危险因素。治疗高血压（BP）和血脂异常的常用方法包括药物治疗，但人们质疑天然来源是否足以降低 CVD 风险因素。我们研究了樱桃汁对老年人血脂谱、血压、血糖、胰岛素和稳态模型评估-胰岛素抵抗（HOMA-IR）的影响。在这项随机对照临床试验中，将 17 名男性和 20 名年龄在 65-80 岁之间的女性随机分配每天饮用 480 毫升樱桃汁或对照饮料，持续 12 周。对照饮料的能量和糖含量相匹配。在基线和饮用樱桃汁或对照饮料 12 周后评估了结局变量。收缩压和低密度脂蛋白胆固醇（LDL）表现出治疗与时间的交互作用。在研究结束时，樱桃组的参与者 LDL 胆固醇水平较低（差异为-20.6，P = 0.001）和总胆固醇（差异为-19.11，P = 0.01），血糖水平较高（差异为 7.94，P = 0.001）、甘油三酯（差异为 6.66，P = 0.01）和 BMI（差异为 1.06，P = 0.02）高于对照组。樱桃汁和对照饮料均未显著改变体重、高密度脂蛋白胆固醇、舒张压、胰岛素和 HOMA-IR。我们的研究结果表明，樱桃汁可以降低收缩压和 LDL 胆固醇水平。然而，需要更大和更长时间的随访研究来进一步评估樱桃汁的心脏保护作用。
