Botha J H, Robinson K M, Ramchurren N, Reddi K, Norman R J
J Natl Cancer Inst. 1986 Jun;76(6):1053-6.
Prostaglandin production by two continuous human esophageal carcinoma cell lines HCU 18 and HCU 39 derived from poorly and moderately differentiated source tumors, respectively, was investigated. Behavior of both lines in vitro and upon sc inoculation into athymic randombred BALB/c nude mice was also assessed. Approximately half the xenografts induced by HCU 18 cells were invasive, whereas those initiated by HCU 39 cells were all well encapsulated. Although metastases were not detected in mice given injections of HCU 39 cells, metastatic tumors developed in 2 mice inoculated with HCU 18 cells. In addition, HCU 18 cells produced significantly more prostaglandin E (PGE) and prostaglandin F (PGF) than HCU 39 cells. These findings suggest a relationship between PGE and PGF production by human esophageal carcinoma cells and their invasive and metastatic potential in athymic mice.
分别从低分化和中分化原发肿瘤中获取的两个人类食管癌细胞系HCU 18和HCU 39的前列腺素生成情况进行了研究。同时评估了这两个细胞系在体外以及皮下接种到无胸腺随机繁殖BALB/c裸鼠后的行为。由HCU 18细胞诱导产生的异种移植瘤约有一半具有侵袭性，而由HCU 39细胞起始的异种移植瘤均被良好包裹。尽管在注射HCU 39细胞的小鼠中未检测到转移瘤，但在接种HCU 18细胞的2只小鼠中出现了转移性肿瘤。此外，HCU 18细胞产生的前列腺素E（PGE）和前列腺素F（PGF）明显多于HCU 39细胞。这些发现表明人食管癌细胞产生PGE和PGF与其在无胸腺小鼠中的侵袭和转移潜能之间存在关联。
